2801-28-7Relevant academic research and scientific papers
Transition-Metal-Free Regioselective C–H Bond Fluorination of 8-Amidoquinolines with Selectfluor
Chen, Hao,Li, Pinhua,Wang, Min,Wang, Lei
supporting information, p. 2091 - 2097 (2018/05/31)
A simple and efficient transition-metal-free protocol for the regioselective C–H bond fluorination of 8-aminoquinoline scaffolds with Selectfluor was developed. The reaction has a broad substrate scope and provides facile access to the corresponding C-5 f
A 1H and 13C NMR Spectral Study of the TONIC and peri-Proximity Effects in some Methylnitroquinolines and a Re-examination of the Nitration of 2,4-Dimethylquinone
Osborne, Alan G.,Hurst, Lee J.
, p. 1327 - 1366 (2007/10/03)
A NMR spectral study of some 4-methyl-5-nitro-quinoline derivatives is reported. In the proton spectrum, characteristic reduced deshielding effects are observed at H-6 as a consequence of the TONIC (Twisted Orthogonal Nitro Induced Chemical shift) effect. The peri-proximity effect for the Me/NO2 couple in 13C NMR is dominated by the rotation of the nitro group. Comparisons with the Me/Me and NO2/NO2 peri-couples are made. Nitration of 2,4-dimethylquinoline gives the 5-, 6- and 8-nitrocompounds in the ratio 13:26:61.
