280107-27-9Relevant academic research and scientific papers
Kinetic study of various phosphoramidite ligands in the iridium-catalyzed allylic substitution
Polet, Damien,Alexakis, Alexandre
, p. 1621 - 1624 (2007/10/03)
(Graph Presented) A comparative kinetic study of seven ligands is presented which clearly shows that a slight difference in the substitution pattern of the aryl group on the amine moiety of the ligand dramatically alters the activity of the resulting iridium catalyst. Ligand L6 shows the most impressive kinetics as well as the highest enantioselectivities.
Diastereoselective synthesis of (5R,7R)- and (5R,7S)-5,7-dimethyl-6,7- dihydro-5H-dibenz[c,e]azepines
Saudan, Lionel A.,Bernardinelli, Gérald,Kündig, E. Peter
, p. 483 - 486 (2007/10/03)
Starting from (R)-1-(2-methoxyphenyl)ethylamine, the title compounds were synthesized. Key steps are a diastereoselective imine alkylation and a Pd-catalyzed biaryl coupling. The benzylic stereogenic centers of the (5R,7R)-azepine induce a strong bias for
