280111-50-4

Basic information

• Product Name: Benzyl 4-(2-(tert-butoxycarbonyl)hydrazinyl)piperidine-1-carboxylate
• Synonyms: Benzyl 4-(2-(tert-butoxycarbonyl)hydrazinyl)piperidine-1-carboxylate;benzyl 4-({[(tert-butoxy)carbonyl]amino}amino)piperidine-1-carboxylate;4-(N'-tert-Butoxycarbonyl-hydrazino)-piperidine-1-carboxylic acid benzyl ester;benzyl 4-[2-[(2-methylpropan-2-yl)oxycarbonyl]hydrazinyl]piperidine-1-carboxylate;N-CBZ-4-(N-BOC-hydrazino)-piperidine;Benzyl 4-[2-(tert-butoxycarbonyl)hydrazino]piperidine-1-carboxylate
• CAS NO: 280111-50-4
• Molecular Formula: C₁₈H₂₇N₃O₄
• Molecular Weight: 349.42468
• Mol File: 280111-50-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Benzyl 4-(2-(tert-butoxycarbonyl)hydrazinyl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyl 4-(2-(tert-butoxycarbonyl)hydrazinyl)piperidine-1-carboxylate(280111-50-4)
• EPA Substance Registry System: Benzyl 4-(2-(tert-butoxycarbonyl)hydrazinyl)piperidine-1-carboxylate(280111-50-4)

Safety Data

• Hazardous Substances Data: 280111-50-4(Hazardous Substances Data)

Usage

General Description

Benzyl 4-(2-(tert-butoxycarbonyl)hydrazinyl)piperidine-1-carboxylate is a chemical compound that is commonly used in the field of organic chemistry. It is a derivative of piperidine, a six-membered heterocyclic ring structure. The compound contains a benzyl group, a piperidine ring, and a carboxylate ester group, as well as a hydrazinyl group protected by a tert-butoxycarbonyl (Boc) group. Benzyl 4-(2-(tert-butoxycarbonyl)hydrazinyl)piperidine-1-carboxylate is often utilized as a precursor in the synthesis of various pharmaceuticals and fine chemicals due to its unique structural features and reactivity. Its functional groups can be selectively modified to produce a wide variety of derivatives with potential biological and medicinal applications. Additionally, the compound's stability and ease of handling make it a valuable building block in organic synthesis.

Upstream product

• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 870-46-2 t-butoxycarbonylhydrazine 
• 501-53-1 benzyl chloroformate 
• 863560-00-3 benzyl 4-(2-(tert-butoxycarbonyl)hydrazono)piperidine-1-carboxylate 

Downstream Products

• 280111-51-5 4-hydrazino-piperidine-1-carboxylic acid benzyl ester 
• 916831-70-4 2-(1-((benzyloxy)carbonyl)piperidin-4-yl)hydrazin-1-ium chloride 
• 1079396-31-8 benzyl 4-(4-chloro-1H-pyrazolo[3,4-d]|pyrimidin-1-yl)piperidine-1-carboxylate 

Relevant articles and documents

A novel and efficient synthesis of 2,5-substituted 1,2,4-triazol-3-ones

A novel procedure for preparing 1,2,4-triazol-3-ones is described. Various alkyl, aryl, and heterocyclic groups were introduced successfully at both the N2 and C5 positions. The triazolone ring was constructed through an intramolecular cyclization of a novel acyclic precursor, which in turn was synthesized by treating a mono protected hydrazine with an acyl isocyanate. Under conditions that remove the hydrazine protecting group, the intramolecular cyclization occurs rapidly, to deliver the 2,5-substituted 1,2,4-triazol-3-ones in excellent yields (79-99%) without column purification.

Compound capable of degrading BTK kinase as well as preparation method and pharmaceutical application of compound

The invention relates to a compound shown in a general formula (I) or a stereoisomer, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or a co-crystal of the compound, as well as an intermediate and preparation method of the compound, and application of the compound in BTK related diseases such as tumors or autoimmune system diseases. And B-L-K (I).

PI3K (DELTA) SELECTIVE INHIBITORS

Novel PI3K, especially PI3K delta isoform, selective inhibitors are disclosed. The compounds are useful in treating disorders related to abnormal PI3K or PI3Kδ activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.