280119-63-3

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 51337-35-0 cyano-(4-methoxy-phenylhydrazono)-acetic acid ethyl ester 
• 104-94-9 4-methoxy-aniline 
• 280119-62-2 3-ethyl-5-methyl (1-[4-Methoxyphenyl]-4-azido)pyrazole-3,5-dicarboxylate 
• 280119-61-1 3-Ethyl-5-methyl (1-[4-Methoxyphenyl]-4-amino)pyrazole-3,5-dicarboxylate 

Downstream Products

• 280120-64-1 3-bromomethyl-6-(4-bromo-phenyl)-1-(4-methoxy-phenyl)-5-methyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one 
• 280119-65-5 1-[4-methoxyphenyl]-3-(ethoxycarbonyl)-6-[4-bromophenyl]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one 
• 280120-61-8 1-(4-Methoxyphenyl)-3-(hydroxymethyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one 
• 903876-84-6 4-amino-5-(4-bromo-phenylcarbamoyl)-1-(4-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester 
• 280120-62-9 6-(4-bromo-phenyl)-1-(4-methoxy-phenyl)-5-methyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid 
• 280119-64-4 1-[4-methoxyphenyl]-3-(ethoxycarbonyl)-4-azido-5-[4-bromophenylaminocarbonyl]pyrazole 
• 903876-90-4 6-(4-bromo-2-fluoro-phenyl)-1-(4-methoxy-phenyl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid ethyl ester 
• 280120-60-7 1-(4-Methoxyphenyl)-3-(ethoxycarbonyl)-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one 
• 280120-63-0 1-(4-Methoxyphenyl)-3-[(imidazol-1-yl)methyl]-5-methyl-6-[(4-bromophenyl)]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one 
• 903876-86-8 4-amino-5-(4-bromo-2-fluoro-phenylcarbamoyl)-1-(4-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester 
• 903876-83-5 4-azido-5-(4-bromo-2-fluoro-phenylcarbamoyl)-1-(4-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester 
• 280119-66-6 6-(2'-formyl-biphenyl-4-yl)-1-(4-methoxy-phenyl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid ethyl ester 
• 903876-93-7 6-(2'-hydroxymethyl-biphenyl-4-yl)-1-(4-methoxy-phenyl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid ethyl ester 
• 903876-94-8 6-(2'-bromomethyl-biphenyl-4-yl)-1-(4-methoxy-phenyl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa

Previously, potent factor Xa inhibitors were described based on a pyrazole core. Modifications of the pyrazole core have provided additional novel, highly potent factor Xa inhibitors. This manuscript will describe the synthesis and biological activity of

Nitrogen containing heterobicycles as factor Xa inhibitors

The present application describes nitrogen containing heterobicyclics and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.