280137-25-9

Upstream product

• 503-87-7 2-thiohydantoin 
• 2286-35-3 ethyl 3-(4-chlorophenyl)-2-cyanoacrylate 
• 104-88-1 4-chlorobenzaldehyde 
• 1026441-44-0 ethyl (2Z)-3-(4-chlorophenyl)-2-isothiocyanatoprop-2-enoate 

Downstream Products

• 129228-63-3 Z-6-(4-Chlorobenzylidene)-2,3-dihydroimidazo-<2,1-b>-thiazol-5(6H)-one 
• 280137-37-3 5-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-3-piperidin-1-ylmethyl-2-thioxo-imidazolidin-4-one 
• 207982-87-4 4-(4-chlorobenzylidene)-2-(4-methylpiperazin-1-yl)-1H-imidazol-5(4H)-one 
• 280137-31-7 5-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-3-morpholin-4-ylmethyl-2-thioxo-imidazolidin-4-one 
• 162713-44-2 ethyl N-<5-(4-chlorobenzylidene)-4-oxo-2-imidazolidinyl>glycinate 
• 162713-43-1 N-<5-(4-chlorobenzylidene)-4-oxo-2-imidazolidinyl>glycine 

Relevant academic research and scientific papers

5-Arylideneimidazolones with amine at position 3 as potential antibiotic adjuvants against multidrug resistant bacteria

Searching for new chemosensitizers of bacterial multidrug resistance (MDR), chemical modifications of (Z)-5-(4-chlorobenzylidene)-2-(4-methylpiperazin-1-yl)-3H-imidazol-4(5H)-one (6) were performed. New compounds (7–17), with fused aromatic rings at posit

Synthesis of dispirooxindoles containing N-unsubstituted heterocyclic moieties and study of their anticancer activity

A convenient method is proposed for the synthesis of N-unsubstituted spiroxindoles with different heterocyclic moieties (2-thiohydantoin, hydantoin, and thiazolidine) by the regio-selective 1,3-dipolar cycloaddition of azomethine ylides, generated from is

Bicyclic imidazole-4-one derivatives: A new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55

GPR18 and GPR55 are orphan G protein-coupled receptors (GPCRs) that interact with certain cannabinoid (CB) receptor ligands. In the present study bicyclic imidazole-4-one derivatives were discovered as new scaffolds for the development of antagonists for

Synthesis of 5-arylidene-2-amino-4-azolones and evaluation of their anticancer activity

Series of novel 5-arylidene-2-arylaminothiazol-4(5H)-ones and 2-aryl(benzyl)amino-1H-imidazol-4(5H)-ones were synthesized from appropriate 2-alkylthioazol-4-ones using nucleophilic substitution in position 2 by various anilines and benzylamines and Knoeve

The synthesis of 2-alkylthio-3-alkyl-5-arylmethylidene-4H-imidazol-4-ones

2-alkylthio-3-alkyl-5-arylmethylidene-4H-imidazol-4-ones were synthesized by the S-alkylation and N-alkylation of 2-thioxo-5-arylmethylidene-4- imidazolidinones, which were obtained via a tandem aza-Wittig reaction of vinyliminophosphoranes, carbon disulf

Synthesis and schistosomicidal activity of new substituted thioxo-imidazolidine compounds

Synthesis and physico-chemical properties of 3-benzyl-5-(4-fluoro- benzylidene)-1-methyl-2-thioxo-imidazolidin-4-ones, 5-benzylidene-3-(4-nitro- benzyl)-2-thioxo-imidazolidin-4-onesand4-acridin-9-ylmethylene-1-benzyl-5- thioxo-imidazolidin-2-ones compounds are described. These thioxo-imidazolidine derivatives were prepared by alkylation and condensation with 4-fluoro-benzaldehyde or nucleophilic Michael addition with cyanoacrylates. The schistosomicidal activity of 3-benzyl-5-(4-fluoro-benzylidene)-1-methyl-2- thioxo-imidazolidin-4-one compounds was evaluated.

Structure and activity studies of glycine receptor ligands. Part 8. Arylidene-imidazoline-4-one aminoacids

Based on chemical and preliminary biological experiments (inhibition to glycine receptor), structure and activity relationship of arylidene-imidazoline-4-one amino acids has been studied. In the course of our work, the simulation of the hydrogen bonds formation between ligand molecule and hypothetical receptor has been designed. Computed interactions are going to simulate possible ligand-receptor interaction with selected amino acids (in this investigation - with basic lysine and acidic aspartic acid). Obtained model estimates roughly the binding energy of the amino acids with ligand molecules. The proposed amino acids binding energies approximately agree with activity of the isomeric benzylidene-imidazoline-4-one glycines and α-alanines which decreases in the order of m-Cl > p-Cl > o-Cl substituents in benzylidene moiety. Additionally, the lowering of activity is caused by lipophilic pocket volume.

Synthesis, conformational analysis and antitumor testing of 5-(Z)-arylidene-4-imidazolidinone derivatives

A series of 5-(Z)-arylidene-2-amino-4-imidazolidinones 16-34, 5-(Z)-arylidene-2-(2-carboxyphenylamino)-4-imidazolidinones 35-41, 5-(Z)-arylidene-3-aminomethyl-2-thioxo-4-imidazolidinones 42-55 and 5-(Z)-arylidene-3-aminomethyl-2-methylmercapto-4-imidazoli