2286-35-3

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 32884-52-9 1-(4-{[(4-chlorophenyl)methylene]amino}phenyl)ethanone 
• 52906-62-4 3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester 
• 3395-81-1 4-chlorobenzaldehyde dimethyl acetal 
• 64-17-5 ethanol 
• 107-91-5 cyanoacetic acid amide 
• 873-76-7 para-Chlorobenzyl alcohol 
• 105-34-0 methyl 2-cyanoacetate 

Downstream Products

• 62966-28-3 4-(4-Chloro-phenyl)-1-cyano-2,2,3,3-tetramethoxy-cyclobutanecarboxylic acid ethyl ester 
• 65576-63-8 5-amino-7-(4-chlorophenyl)-2-[(4-chlorophenyl)methylene]-2,3-dihydro-3-oxo-7H-thiazolo[3,2-a]pyridine-6,8-dicarboxylic acid 6,8-diethyl ester 
• 133620-71-0 ethyl 2-amino-4-(p-chlorophenyl)-4H-pyrano<3,2-h>quinoline-3-carboxylate 
• 94988-85-9 ethyl 7‐amino‐5‐(4‐chlorophenyl)‐2,4‐dioxo‐1,3,4,5‐tetrahydro‐2H‐pyrano[2,3‐d]pyrimidine‐6‐carboxylate 
• 132524-78-8 ethyl 2-amino-4-(4-chlorophenyl)-6-methyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c] quinoline-3-carboxylate 
• 111783-11-0 3-amino-4-cyano-5-(p-chlorophenyl)benzocoumarin 
• 102423-78-9 4-(4-chlorophenyl)-1,2-dihydro-6-hydroxy-2-thioxo-3,5-pyridinedicarbonitrile 
• 133149-40-3 3-Amino-1-(4-chloro-phenyl)-9-oxo-9H-fluorene-2,4-dicarbonitrile 
• 108005-47-6 2-(4-chlorophenyl)succinonitrile 
• 131387-86-5 4-(4-chlorophenyl)-2-oxo-3-(1-pyridino)-5-cyano-3,4-trans-1,2,3,4-tetrahydro-6-pyridinolate 
• 93032-54-3 (Z)-3-(4-Chloro-phenyl)-2-(4-oxo-4,5-dihydro-thiazol-2-yl)-acrylonitrile 
• 129680-13-3 5-Amino-7-(4-chloro-phenyl)-2-[1-(4-chloro-phenyl)-meth-(E)-ylidene]-3-oxo-2,3-dihydro-7H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 129650-75-5 5-Amino-7-(4-chloro-phenyl)-2-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-3-oxo-2,3-dihydro-7H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 93032-53-2 5-Amino-8-carbamoyl-7-(4-chloro-phenyl)-2-[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-6-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Highly active zinc oxide-supported lithium oxide catalyst for solvent-free Knoevenagel condensation

Li2O/ZnO catalyst was prepared by wet impregnation method and characterized by XRD, SEM, EDX, FTIR, BET surface area and UV-Vis diffuse reflectance spectroscopy. This study revealed a decrease in average particle size and change in the shape of

Synthesis of lithium/cesium-Zagronas from zagrosian natural asphalt and study of their activity as novel, green, heterogeneous and homogeneous nanocatalysts in the Claisen–Schmidt and Knoevenagel condensations

A novel, heterogeneous and homogeneous basic nanocatalysts were synthesized by grafting of lithium and cesium on zagrosian natural asphalt sulfonate (Li/Cs-Zagronas). The activity of these catalysts was examined in the Claisen–Schmidt and Knoevenagel condensations under mild reaction conditions. Li/Cs-Zagronas were characterized by FT-IR spectroscopy, scanning electron microscopy, X-ray diffraction, energy-dispersive spectroscopy, inductively coupled plasma and thermogravimetric analysis techniques. These nanocatalysts were removed by simple filtration and reused several times without any deterioration of activity.

Bis [hydrazinium (1+)] hexafluoridosilicate:(N2H5)2SiF6 novel hybrid crystal as an efficient, reusable and environmentally friendly heterogeneous catalyst for Knoevenagel condensation and synthesis of biscoumari

A simple, effective, green and nontoxic protocol was used for the Knoevenagel condensation and the biscoumarin derivatives synthesis. It have demonstrated that the use of a new hybrid crystal as a heterogeneous catalyst makes it possible to obtain several

A Simple and Highly Versatile Procedure for the Knoevenagel Condensation Promoted by an Efficient, Eco-Friendly, and Recyclable nano-ZnO Catalyst

Abstract: A simple, highly versatile, and efficient protocol for the synthesis of substituted olefins from various aromatic aldehydes and active methylene compounds by Knoevenagel condensation using an efficient, eco-friendly, and recyclable nano-ZnO cata

Ammonium chloride: An efficient and environmentally benign catalyst for knoevenagel condensation of carbonyl and active methylene compounds

In the present study, a rapid, simple and an efficient procedure for the Knoevenagel condensation of various carbonyl and active methylene compounds in ethanol at a moderate temperature in the presence of a catalytic amount of an efficient, environmentall

Potassium Natural Asphalt Sulfonate (K-NAS): Synthesis and characterization as a new recyclable solid basic nanocatalyst and its application in the formation of carbon–carbon bonds

In this research, we synthesized and characterized a new heterogeneous basic nanocatalyst and its catalytic application was studied in the Claisen-Schmidt and Knoevenagel condensations. In order to prepare this nanocatalyst, first, the Iranian natural asphalt was sulfonated with the concentrated sulfuric acid and then, converted to the potassium natural asphalt sulfonate (K-NAS). In order to characterization of the nanocatalyst, used of FT-IR spectroscopy, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), inductively coupled plasma (ICP) and thermogravimetric analysis (TGA) techniques. This new basic heterogeneous nanocatalyst have advantages such as being eco-friendly, huge specific surface area, high reactivity and recyclability.

A facile microwave-assisted Knoevenagel condensation of various aldehydes and ketones using amine-functionalized metal organic frameworks

An amine-functionalized metal organic framework (MOF) was used as highly efficient and recyclable heterogeneous catalyst for Knoevenagel condensation of various aromatic aldehydes and ketones in ethanol. The catalytic efficiency was demonstrated by the hi

Bismuth (III) Triflate: A Mild, Efficient Promoter for the Synthesis of Trisubstituted Alkenes through Knoevenagel Condensation

In this work, smooth efficient and eco-friendly two component coupling method is reported for the synthesis of Knoevenagel Condensation product in presence of Bi(OTf)3 catalyst under solvent free condition. Catalyst has participated in condensation between substituted aldehydes (aromatic and hetero-aromatic) and active methylene compounds (ethyl cyanoacetate, malononitrile and cyanoacetamide) effectively to generate an excellent yield of the product. Bi(OTf)3 catalyst is stable, inexpensive and easily available was used for four times in this reaction without loss of catalytic activity. [Formula Presented]

Overcoming acid–base copolymer neutralization using mesoporous carbon and its catalytic activity in the tandem deacetalization–Knoevenagel condensation reaction

Abstract: Acid–base copolymer materials are of considerable interest because of their fundamental implications for acid–base bifunctional catalysis applications. However, quenching the acid and base sites of the copolymer with each other in free radical polymerizations is still challenging. Herein, we demonstrate that the polymerization of styrenesulfonic acid-co-4-vinylpyridine into the mesoporous carbon material (i.e., CMK-3) can control the chain growth polymerization and result in decreasing the interaction of the acid–base sites. The results showed that by using CMK-3, 40% of the acid and base sites of the copolymer remain in their original form while 60% of acid and base sites convert to the pyridinium and sulfonate forms. Furthermore, it is demonstrated that this material can be processed as a heterogeneous bifunctional acid–base catalyst in the tandem one-pot acid–base reaction (i.e., deacetalization–Knoevenagel condensation reaction) with a high catalytic activity in aqueous media. Graphic abstract: [Figure not available: see fulltext.].

Precise Control of the Oriented Layered Double Hydroxide Nanosheets Growth on Graphene Oxides Leading to Efficient Catalysts for Cascade Reactions

In recent years, great attention has been paid to cascade reactions, which can improve efficiency and reduce waste production by implementing several consecutive reactions. Herein, two bifunctional catalysts were successfully prepared by precise control of the oriented layered double hydroxides (LDHs) growth on graphene oxides (GO) using a single-drop and co-precipitation method, respectively. The resultant Ru/LDH-GO-P and Ru/LDH-GO-V composites were characterized by EXAFS, FT-IR, XRD, TG-DTA, BET, XPS, TEM, CO2-TPD, O2-TPD, etc. The catalytic performance of Ru/LDH-GO-P and Ru/LDH-GO-V for one-pot oxidation-Knoevenagel condensation reaction showed significant difference under the same experimental conditions, in which the Ru/LDH-GO-P showed 99 % conversion and 99 % selectivity, in marked contrast of 60.7 % conversion and 47.9 % selectivity using Ru/LDH-GO-V as catalyst. The large enhancement of the catalytic performance using Ru/LDH-GO-P can be attributed to the following reasons: 1) the Co3+ centers in Ru/LDH-GO-P can promote the formation of surface oxygen vacancies that can adsorb and activate O2 to get better performance; 2) the Ru/LDH-GO-P exhibited larger BET surface and more medium-strong basic active sites than the Ru/LDH-GO-V. Moreover, the Ru/LDH-GO-P catalyst can be easily recovered from the reaction system and reused for at least five times without obvious deterioration of its catalytic activity or structural integrity.