280141-27-7Relevant academic research and scientific papers
Preparation of oxime dual NK1/NK2 antagonists with reduced NK3 affinity
Reichard, Gregory A,Grice, Cheryl A,Shih, Neng-Yang,Spitler, James,Majmundar, Sapna,Wang, Steven D,Paliwal, Sunil,Anthes, John C,Piwinski, John J
, p. 2355 - 2358 (2002)
By employing a stereosimplification approach, a thorough SAR exploration of the piperidine region of Sch 206272 was possible through a practical and efficient synthesis of substituted cyclic ureas. This SAR study led to the identification of a benzimidazolinone series of compounds which display single digit nanomolar NK1/NK2 affinity and near micromolar binding for the NK3 receptor.
