280141-74-4

Usage

Chemical class

Imidazolidine derivative

Explanation

The compound belongs to the class of imidazolidine compounds, which are known for their various biological activities.

Explanation

The compound has potential applications in the pharmaceutical industry due to its unique structure and properties.

Explanation

The presence of a benzylpiperidine moiety in the compound is associated with central nervous system activity, which is a common characteristic in many drugs.

Explanation

The imidazolidin-2-one group in the compound may contribute to its potential anti-inflammatory and anti-cancer properties.

Explanation

Due to its unique structure and potential biological activities, 1-(1-benzylpiperidin-4-yl)imidazolidin-2-one could be a valuable molecule for the development of new drugs targeting various medical conditions.

Explanation

The benzylpiperidine moiety is commonly found in drugs that affect the central nervous system, suggesting that 1-(1-benzylpiperidin-4-yl)imidazolidin-2-one may have similar effects.

Explanation

The presence of the imidazolidin-2-one group in the compound may provide it with anti-inflammatory properties, which could be useful in the development of treatments for inflammation-related conditions.

Explanation

The imidazolidin-2-one group may also contribute to the compound's potential anti-cancer properties, making it a candidate for further research in cancer treatment.

Biological activity

Potential pharmaceutical use

Structural feature

Benzylpiperidine moiety

Additional functional group

Imidazolidin-2-one

Potential applications

Drug development

Central nervous system activity

Possible due to benzylpiperidine moiety

Anti-inflammatory potential

Suggested by imidazolidin-2-one group

Anti-cancer potential

Suggested by imidazolidin-2-one group

Upstream product

• 50541-93-0 4-amino-1-benzylpiperidine 
• 280141-48-2 tert-butyl 2-(1-benzylpiperidin-4-ylamino)ethylcarbamate 
• 1943-83-5 2-chloroethyl isothiocyanate 
• 308362-93-8 N₁-(1-benzylpiperidin-4-yl)ethane-1, 2-diamine 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 72338-84-2 1-(1-benzylpiperidin-4-yl)-3-methylimidazolidin-2-one 

Relevant academic research and scientific papers

Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2

Melanin concentrating hormone receptor 1 (MCHR1) antagonists have potential for the treatment of obesity and several CNS disorders. In the preceding article, we have described a novel series of quinazolines as MCHR1 antagonists and demonstrated in vivo proof of principle with an early lead. Herein we describe the detailed SAR and SPR studies to identify an optimized lead candidate having good efficacy in a sub-chronic DIO model with a good cardiovascular safety window.

PIPERIDINYL CYCLIC AMIDO ANTIVIRAL AGENTS

Provided are compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).

SUBSTITUTED OXIMES AND HYDRAZONES AS NEUROKININ ANTAGONISTS

Compound represented by structural formula (I) or a pharmaceutical acceptable salt thereof, wherein a is 0-3; b, d and e are 0-2; R is H, alkyl, F or -OR; A is an optionally substituted oxime or hydrazone; d is not 0 and X is a bond, -C(O)-, -O-, -NR-, -S(O)e-, -N(R)C(O)-, -C(O)N(R)-, -OC(O)NR-, -OC(=S)NR-, -N(R)C(=S)O-, -S(O)2N(R)-, -N(R)S(O)2-, -N(R)C(O)O-, -OC(O)- or -N(R)C(O)NR-; or d is 0 and X is a bond or -NR-; T is H, aryl, heterocycloalkyl or heteroaryl; Q is phenyl, napthyl or heteroaryl; R is H, alkyl, hydroxyalkyl, alkoxyalkyl, phenyl, and benzyl; R is R or -OR, R, R, R and R are H or alkyl; Z is a nitrogen-containing heterocyclo group, e.g., piperidinyl, substituted by a heterocyclo- or heterocycloalkyl group; wherein phenyl, benzyl, aryl, heterocycloalkyl, heteroaryl and cycloalkyl groups are optionally substituted; methods of treating diseases such as asthma, cough, bronchospasm, depression, emesis, inflammatory diseases, and gastrointestinal disorders with said compounds, and pharmaceutical compositions comprising said compounds are disclosed.