28026-16-6

Usage

Uses

Used in Pharmaceutical Industry:
N-ACETYL-5-ACETOXYTRYPTAMINE is used as a prodrug for delivering across the blood-brain barrier, allowing for better access to the central nervous system and potentially improving the efficacy of treatments for neurological conditions.
Used in Neurodegenerative Disease Treatment:
N-ACETYL-5-ACETOXYTRYPTAMINE is used as a therapeutic agent for treating neurodegenerative diseases, such as Alzheimer's, Parkinson's, and other conditions that involve the progressive loss of nerve cells in the brain. Its ability to cross the blood-brain barrier makes it a valuable tool in the development of new treatments for these diseases.

Upstream product

• 153-98-0 serotonin hydrochloride 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 

Downstream Products

• 73-31-4 5-methoxy-N-acetyl-tryptamine 
• 1210-83-9 N-acetyl-5-hydroxytryptamine 
• 608-07-1 2-(5-methoxyindol-3-yl)ethylamine 

Relevant academic research and scientific papers

COMPOUNDS DERIVED FROM 3-ALKYLAMINO-1H-INDOLE ACRYLATE, AND THE USE THEREOF IN THE TREATMENT OF NEURODEGENERATIVE DISEASES

The invention relates to the methods for producing derivatives of 3-alkylamino-1H-indole acrylate (I) with transcription factor Nrf2-inducing activity, free radical scavenging activity and neuroprotective ability. The invention also relates to the use of the derivatives according to the invention for the treatment of diseases, the pathogenesis of which involves oxidative stress, or diseases involving the deregulation of the activity of phase II genes activated by the factor Nrf2, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, ictus or amyotrophic lateral sclerosis.

SEPIAPTERIN REDUCTASE INHIBITORS FOR THE TREATMENT OF PAIN

Disclosed herein are small molecule heterocyclic inhibitors of sepiapterin reductase (SPR), and pro-drugs and pharmaceutically acceptable salts thereof. The Also featured are pharmaceutical compositions of the compounds and uses of these compounds for the treatment or prevention of pain (e.g., inflammatory pain, nociceptive pain, functional pain, and neuropathic pain)

Synthesis and evaluation of the antiovulatory activity of a variety of melatonin analogues

A series of melatonin analogues was synthesized and examined for ovulation-blocking activity. Deviation from the 5-methoxy group or substitution of the 1 position prevented activity. Activity was not particularly sensitive to minor variations in the N-acyl group nor was it significantly altered by methylation of position 2 or the α-methylene; however, a pronounced enhancement resulted from halogenation of the 6 position.