2803-00-1Relevant articles and documents
Identification of a suspicious drug by using spectroscopic techniques: A forensic analytical chemistry project
Msimanga, Huggins Z.,Everhart, Gregory P.
, p. 161 - 166 (2012)
We identified a drug analog by using screening and confirmatory tests. Total ion chromatogram showed a major peak with a molecular ion of 190m/z, but no mass spectrum match from the NIST library. A minor peak was identified as 1-benzylpiperazine (molecular ion = 176m/z). Molecular ions of both peaks differed by 14m/z units, suggesting a -CH2 - group. Both peaks had the same base peak of 91m/z. Derivatizing the drug analog with trifluoroacetic anhydride confirmed the presence of 1-benzylpiperazine. No reaction occurred with the major peak. We proposed a benzyl-4-methylpiperazine structure, which was confirmed by NMR studies. Copyright
Mild N-dealkylation of tertiary, benzylic amines with acid chlorides: Application to solid-phase chemistry
Miller, Michael W.,Vice, Susan F.,McCombie, Stuart W.
, p. 3429 - 3432 (2007/10/03)
A mild, facile cleavage of appropriately substituted tertiary benzylic amines with acid chlorides is described for both solution and solid phase.
Synthesis of Piperazines and Thiomorpholines by Ozonolysis of Cyclic Olefins and Reductive N-Alkylation
Kawaguchi, Mamoru,Hayashi, Osamu,Kanamoto, Masahiro,Hamada, Masayuki,Yamamoto, Yukio,Oda, Jun'ichi
, p. 435 - 440 (2007/10/02)
Ozonized 1-trifluoroacetyl-3-pyrroline (2a) and 3-sulfolene (6) were reduced with sodium cyanoborohydride (1) to afford the dialdehyde, which reacted in situ with the primary amines 3ad in the presence of 1 to give the piperazines 4ad (2160 percent) and the dioxothiomorpholines 7ad (2676 percent).Reduction of 7a and 7c with diisobutylaluminum hydride yielded the thiomorpholines 8a and 8c, respectively.On the other hand, the 9-membered azacrown ethers 10 and 11 were obtained when N,N'-dibenzylethylenediamine (9) was employed.The dioxothiomorpholine derivatives 13 of amino acids were also prepared by the same treatment.
