28030-15-1

Basic information

• Product Name: BENZENEPROPANOIC ACID, A-HYDROXY-4-METHOXY-
• Synonyms: BENZENEPROPANOIC ACID, A-HYDROXY-4-METHOXY-
• CAS NO: 28030-15-1
• Molecular Formula: C₁₀H₁₂O₄
• Molecular Weight: 196.2
• Mol File: 28030-15-1.mol

Chemical Properties

• Melting Point: 88 °C
• Boiling Point: 372.9±27.0 °C(Predicted)
• Appearance: /
• Density: 1.263±0.06 g/cm3(Predicted)
• PKA: 3.78±0.10(Predicted)
• CAS DataBase Reference: BENZENEPROPANOIC ACID, A-HYDROXY-4-METHOXY-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZENEPROPANOIC ACID, A-HYDROXY-4-METHOXY-(28030-15-1)
• EPA Substance Registry System: BENZENEPROPANOIC ACID, A-HYDROXY-4-METHOXY-(28030-15-1)

Safety Data

• Hazardous Substances Data: 28030-15-1(Hazardous Substances Data)

Usage

Uses

Used in Skincare Products:
Benzenepropanoic acid, a-hydroxy-4-methoxyis used as an active ingredient in skincare products for its antioxidant and anti-inflammatory properties. It helps protect the skin from free radical damage and reduces inflammation, leading to improved skin health and appearance.
Used in Pharmaceutical Preparations:
Benzenepropanoic acid, a-hydroxy-4-methoxyis used as a pharmaceutical agent for its potential health benefits. Its antioxidant and anti-inflammatory properties may contribute to the prevention and treatment of certain diseases, as well as promoting overall well-being.

Upstream product

• 55301-58-1 2-hydroxy-3-(4-methoxyphenyl)propionic acid methyl ester 
• 17131-20-3 3-(4′-methoxyphenyl)-prop-1,2-diol 
• 38618-53-0 ethyl 2-hydroxy-3-(4-methoxyphenyl)propanoate 
• 30193-56-7 (2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4''-methoxyphenyl)-propionic acid methyl ester 
• 42245-42-1 methyl 3-(4-methoxyphenyl)glycidate 
• 105955-68-8 p-methoxybenzyltartronic acid monoamide 
• 133373-30-5 4-(p-methoxyphenyl)-2,3-diketobutyramide hydrate 

Relevant articles and documents

Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids via Hydrogen Atom Transfer

The oxidation of primary alcohols and aldehydes to the corresponding carboxylic acids is a fundamental reaction in organic synthesis. In this paper, we report a new chemoselective process for the oxidation of primary alcohols and aldehydes. This metal-free reaction features a new oxidant, an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcohols and tert-butanesulfinamides.

Enzyme-mediated synthesis of EEHP and EMHP, useful pharmaceutical intermediates of PPAR agonists

A new scaleable synthetic route to the title compounds has been developed. The reaction pathway is based on the α-chymotrypsin-catalysed hydrolysis of the racemic ethyl 2-ethoxy-3-(p-methoxyphenyl)propanoate or of the racemic ethyl 2-methoxy-3-(p-methoxyphenyl)propanoate to give the corresponding resolved (S)-esters with excellent ee. The acids were easily separated from the (S)-esters by a simple acid-base work-up. The overall yields of 1 and 2 were 16% and 17%, respectively.

Unstable 1,1,2-Enetriols as (Probable) Intermediates in the Decarboxylation of α,β-Diketo Acids

During the acid hydrolysis of (hydrated) 4-aryl-2,3-diketobutyramide 2 (aryl = phenyl, o-chlorophenyl, p-methoxyphenyl), 3-aryllactic acid (5) is formed by rapid decarboxylation of the intermediate diketo acid (3).In the decarboxylation step, a further unstable intermediate is formed.The latter manifests itself by reducing 1 mol of added iodine during the hydrolysis-decarboxylation reaction, thereby forming 3-arylpyruvic acid (6), isolated instead of 5.Thus, the oxidation of the unstable intermediate by iodine is more rapid than its ketonization.It is formulated as an 1,1,2-enetriol (4), more probably than an α-hydroxyketone.

225. Nucleofilic 1,2-Shifts of Carboxamide Groups in the Benzil-Benzilic Acid Type Rearrangement of 4-Aryl-2,3-dioxobutyramides and of Quinisantine

4-Aryl-2,3-dioxobutyramide hydrates 1 undergo the benzyl-benzilic acid rearrangemet to form (substituted) benzyltartronate monoamides 2.For compound 1a (Ar = Ph), it is demonstrated by isotopic labeeling that the reaction occurs exclusively by migration of the CONH2 group.Kinetic measurements with 1a-c and with the cyclic amide quinisatine 6 show that the rearrangement of the carboxamide group procceding via an alkali-catalysed step, can reach a plateau in the kobs/-> diagram (cf. the Fig.), due to complet formation of a mono-anion, and a further increase of the rate attributable to the rearrangement of a bis-anion.Comparison suggest that rearrangement involving an amide group are slower than those involving an ester group, and for this effect (as for others), the pre-equilibrium deprotonated of the hydrate is more important than a specific migration tendency.