55301-58-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-3-(4-methoxy-phenyl)-propionic acid ethyl ester is used as a nonsteroidal anti-inflammatory drug (NSAID) for its potential anti-inflammatory, analgesic, and antipyretic properties. It may be employed in the treatment of pain, inflammation, and fever, offering an alternative to traditional NSAIDs.
Used in Drug Development:
As a chemical compound with potential pharmaceutical applications, 2-Hydroxy-3-(4-methoxy-phenyl)-propionic acid ethyl ester is used in drug development for further research and exploration of its therapeutic effectiveness. Its enhanced pharmacokinetic properties, such as absorption and bioavailability, may improve its potential as a pharmaceutical agent for various medical conditions, warranting further investigation into its clinical applications.

Upstream product

• 30193-56-7 (2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4''-methoxyphenyl)-propionic acid methyl ester 
• 96125-49-4 methyl trans-3-(4-methoxyphenyl)glycidate 
• 42245-42-1 methyl 3-(4-methoxyphenyl)glycidate 
• 98081-75-5 2-azido-3-(4-methoxyphenyl)acrylic acid methyl ester 
• 67-56-1 methanol 

Downstream Products

• 123962-84-5 (E)-3-(4-Methoxy-phenyl)-2-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-acrylic acid methyl ester 
• 123962-85-6 (Z)-3-(4-Methoxy-phenyl)-2-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-acrylic acid methyl ester 
• 33173-34-1 2-hydroxy-3-(4-methoxyphenyl)propanoic acid 

Relevant academic research and scientific papers

Asymmetric transfer hydrogenation of α-azido acrylates

The asymmetric transfer hydrogenation of α-azido acrylates has been explored, a range of α-hydroxy esters are produced with good enantioselectivities (80-90% ee). The reaction was conducted in the wet HCO2H/NEt3 with Ru-TsDPEN A.

Regioselective deoxygenation of the cyclic thionocarbonates of 2,3- dihydroxy esters with magnesium in methanol

Deoxygenation of the cyclic thionocarbonates of 2,3-dihydroxy esters was mediated with magnesium in methanol, which provided a facile method for the synthesis of α-hydroxy esters.

Enantioselectivity of Pseudomonas cepacia lipase for the acetylation of 2-hydroxy carboxylic acid esters+

Structurally different ethyl or methyl 2-hydroxy carboxylates were resolved by Pseudomonas cepacia lipase-catalysed acetylations with vinyl acetate in diethylether. One type of the alcoholic substrates (2-hydroxy-2-arylacetates and 2-hydroxy-3-arylpropinates) contained a HO-group at the stereocentre. These compounds were resolved with high enantioselectivity (ee 91 → 99) at ca. 50% conversion. The other alcoholic substrates ((threo-2-hydroxy-3-methylbutyrate and threo- or erythro-2-hydroxy-3-aryl-3-arylthio(or aryloxy)propionates) with two stereocentres generally resulted in enantiopure products and the reactions stopped at 50 % conversion.