28050-87-5

Upstream product

• 115031-71-5 (2S,3R,2'R,4E,8E)-2-(hexadecanoylamino)-4,8-octadecadiene-1,3,2′-triol 
• 67-56-1 methanol 
• 114297-20-0 (2′R)-N-{(1S,2R,3E,7E)-1-[(β-D-glucopyranosyloxy)methyl]-2-hydroxyheptadeca-3,7-dien-1-yl}-2-hydroxyhexadecanamide 
• 87384-99-4 1-O-β-D-glucopyranosyl-2-N-2'-hydroxypalmitoyl-shinga-4,8-diene 

Relevant academic research and scientific papers

Preliminary biological assay on cerebroside mixture from Euphorbia nicaeensis All. Isolation and structure determination of five glucocerebrosides

Preliminary studies of in vitro cytostatic activity on less polar fraction of the MeOH extract of the plant Euphorbia nicaeensis All., carried out on KB cells, have evinced a relatively low ability of extract to inhibit cell growth. Successive, five glucocerebrosides were isolated from the cerebroside molecular species obtained from this extract using normal and reversed phase column 'flash-chromatography'. The structures of these cerebrosides were determined on the basis of chemical and spectroscopic evidences. Mass spectrometry of dimethyl disulfide derivatives was useful for the determination of the double-bond positions in the long-chain bases.

Novel ceramide 1-sulfates, potent DNA topoisomerase I inhibitors isolated from the bryozoa Watersipora cucullata

Two ceramide 1-sulfates 1 and 2 have been isolated from the Japanese Bryozoa Watersipora cucullata as new potent inhibitors of a human DNA topoisomerase I. The gross structures of 1 and 2 were determined by spectroscopic analysis, and their absolute stereochemistry was elucidated by the optical data of degradation products.

The principles of Tetragonia tetragonoides having anti-ulcerogenic activity. II. Isolation and structure of cerebrosides

Compound B1 (tentative name), isolated from Tetrogonia tetragonoides as a principle with anti-ulcerogenic activity, was determined to be a mixture of geometrical isomers of 1-O-β-D-glucopyranosyl-2-N-2'-hydroxypalmitoyl-sphinga-4,8-dienine on the basis of chemical and spectral evidence. By repeated chromatography, compound B1 was separated into compounds B(1-a) (major) and B(1-b) (minor), which were found to be the 4-trans-8-trans and 4-trans-8-cis isomers, respectively. Several cerebrosides and glycolipids from various biological sources were examined for protective activity against the ulcer formation in mice under restraint and water immersion condition.