280556-71-0

Usage

Uses

Used in Pharmaceutical Industry:
(4-MORPHOLIN-4-YL-PHENYL)METHANOL is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new therapeutic agents. Its presence in the molecular structure of potential drugs aids in enhancing their pharmacological properties and effectiveness.
Used in Agrochemical Industry:
In the agrochemical sector, (4-MORPHOLIN-4-YL-PHENYL)METHANOL is utilized as a key component in the creation of agrochemicals, playing a crucial role in the synthesis of compounds that help protect crops and enhance agricultural productivity.
Used in Drug Discovery and Development:
(4-MORPHOLIN-4-YL-PHENYL)METHANOL is employed as a versatile intermediate in drug discovery and development, facilitating the design and synthesis of innovative therapeutic agents. Its unique structural features make it a valuable asset in the creation of compounds with potential medicinal applications.
Used in Organic Synthesis:
As a versatile intermediate, (4-MORPHOLIN-4-YL-PHENYL)METHANOL is used in organic synthesis for the preparation of a wide range of organic compounds. Its ability to form various chemical bonds and participate in different reaction pathways makes it a valuable tool in the synthesis of complex organic molecules.

InChI:InChI=1/C11H15NO2/c13-9-10-1-3-11(4-2-10)12-5-7-14-8-6-12/h1-4,13H,5-9H2

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 7470-38-4 4-morpholin-4-yl-benzoic acid 
• 110-91-8 morpholine 
• 873-75-6 4-bromobenzenemethanol 
• 23676-05-3 4-morpholin-4-yl-benzoic acid methyl ester 

Downstream Products

• 1204-86-0 4-(4-morpholinyl)benzaldehyde 
• 1064708-77-5 4-morpholinobenzyl bromide 
• 1616402-39-1 3-amino-5-(3,5-dimethylisoxazol-4-yl)-1-(4-morpholinobenzyl)pyridin-2(1H)-one 
• 1616403-03-2 C₂₃H₂₆N₄O₄ 
• 1616403-02-1 4-[4-(chloromethyl)phenyl]morpholine hydrochloride 
• 1039998-34-9 4-chloro-N-(4-morpholinobenzyl)aniline 
• 280556-50-5 N₁-(4-Methoxybenzoyl)-N₂-[4-(4-morpholinyl)benzyl]-1,2-benzenediamine 

Relevant academic research and scientific papers

Hydrogenation of Esters by Manganese Catalysts

The hydrogenation of esters catalyzed by a manganese complex of phosphine-aminopyridine ligand was developed. Using this protocol, a variety of (hetero)aromatic and aliphatic carboxylates including biomass-derived esters and lactones were hydrogenated to primary alcohols with 63–98% yields. The manganese catalyst was found to be active for the hydrogenation of methyl benzoate, providing benzyl alcohol with turnover numbers (TON) as high as 45,000. Investigation of catalyst intermediates indicated that the amido manganese complex was the active catalyst species for the reaction. (Figure presented.).

Discovery of N-(Naphthalen-1-yl)-N′-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers

A class of N-(naphthalen-1-yl)-N′-alkyl oxalamides have been proven to be powerful ligands, making a coupling reaction of (hetero)aryl iodides with primary amines proceed at 50 °C with only 0.01 mol % of Cu2O and ligand as well as a coupling reaction of (hetero)aryl bromides with primary amines and ammonia at 80 °C with only 0.1 mol % of Cu2O and ligand. A wide range of coupling partners work well under these conditions, thereby providing an easy to operate method for preparing (hetero)aryl amines.

Antithrombotic amides

This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermidates thereof.