280556-71-0

Basic information

• Product Name: (4-MORPHOLIN-4-YL-PHENYL)METHANOL
• Synonyms: BUTTPARK 98\50-30;(4-MORPHOLINOPHENYL)METHANOL;(4-MORPHOLIN-4-YL-PHENYL)METHANOL;RARECHEM AL BD 1130;(4-MORPHOLIN-4-YL-PHENYL)METHANOL 95%;4-Morpholinobenzyl Alcohol;4-(Morpholin-4-yl)benzyl alcohol;4-(Morpholin-4-yl)benzyl alcohol, 4-[4-(Hydroxymethyl)phenyl]morpholine
• CAS NO: 280556-71-0
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.24
• Product Categories: Alcohols and Derivatives;Heterocycles
• Mol File: 280556-71-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 96 °C
• Boiling Point: 378.4 °C at 760 mmHg
• Flash Point: 182.7 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 2.12E-06mmHg at 25°C
• Refractive Index: 1.568
• PKA: 14.40±0.10(Predicted)
• CAS DataBase Reference: (4-MORPHOLIN-4-YL-PHENYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-MORPHOLIN-4-YL-PHENYL)METHANOL(280556-71-0)
• EPA Substance Registry System: (4-MORPHOLIN-4-YL-PHENYL)METHANOL(280556-71-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 280556-71-0(Hazardous Substances Data)

Usage

General Description

(4-Morpholin-4-yl-phenyl)methanol is a chemical compound with the molecular formula C12H15NO2. It is a white crystalline solid with a molecular weight of 205.25 g/mol. (4-MORPHOLIN-4-YL-PHENYL)METHANOL is a member of the morpholine family and contains a phenyl ring with a morpholine group attached. It is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. This chemical is also known for its applications in drug discovery and development, particularly in the design and synthesis of potential therapeutic agents. Additionally, it has been studied for its potential pharmacological properties and its role as a versatile intermediate in organic synthesis.

InChI:InChI=1/C11H15NO2/c13-9-10-1-3-11(4-2-10)12-5-7-14-8-6-12/h1-4,13H,5-9H2

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 7470-38-4 4-morpholin-4-yl-benzoic acid 
• 23676-05-3 4-morpholin-4-yl-benzoic acid methyl ester 
• 110-91-8 morpholine 
• 873-75-6 4-bromobenzenemethanol 

Downstream Products

• 280556-50-5 N₁-(4-Methoxybenzoyl)-N₂-[4-(4-morpholinyl)benzyl]-1,2-benzenediamine 
• 1039998-34-9 4-chloro-N-(4-morpholinobenzyl)aniline 
• 1064708-77-5 4-morpholinobenzyl bromide 
• 1204-86-0 4-(4-morpholinyl)benzaldehyde 
• 1616402-39-1 3-amino-5-(3,5-dimethylisoxazol-4-yl)-1-(4-morpholinobenzyl)pyridin-2(1H)-one 
• 1616403-03-2 C₂₃H₂₆N₄O₄ 
• 1616403-02-1 4-[4-(chloromethyl)phenyl]morpholine hydrochloride 

Relevant articles and documents

Hydrogenation of Esters by Manganese Catalysts

The hydrogenation of esters catalyzed by a manganese complex of phosphine-aminopyridine ligand was developed. Using this protocol, a variety of (hetero)aromatic and aliphatic carboxylates including biomass-derived esters and lactones were hydrogenated to primary alcohols with 63–98% yields. The manganese catalyst was found to be active for the hydrogenation of methyl benzoate, providing benzyl alcohol with turnover numbers (TON) as high as 45,000. Investigation of catalyst intermediates indicated that the amido manganese complex was the active catalyst species for the reaction. (Figure presented.).

Antithrombotic amides

This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermidates thereof.