7470-38-4

Basic information

• Product Name: 4-Morpholinobenzoic acid
• Synonyms: AKOS B022043;4-MORPHOLINOBENZENECARBOXYLIC ACID;4-MORPHOLINOBENZOIC ACID;4-MORPHOLIN-4-YL-BENZOIC ACID;4-(N-MORPHOLINO)-BENZOIC ACID;ART-CHEM-BB B022043;BUTTPARK 98\50-28;CHEMBRDG-BB 4400213
• CAS NO: 7470-38-4
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.23
• Product Categories: Acids and Derivatives;Heterocycles;pharmacetical;Carboxylic Acids;Phenyls & Phenyl-Het;Carboxylic Acids;Phenyls & Phenyl-Het;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Morpholines/Thiomorpholines
• Mol File: 7470-38-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 278 °C
• Boiling Point: 413.2°Cat760mmHg
• Flash Point: 203.7°C
• Appearance: /
• Density: 1.253g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: 2-8°C
• PKA: 4.70±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• Sensitive: Moisture & Light Sensitive
• CAS DataBase Reference: 4-Morpholinobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Morpholinobenzoic acid(7470-38-4)
• EPA Substance Registry System: 4-Morpholinobenzoic acid(7470-38-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 7470-38-4(Hazardous Substances Data)

Usage

Uses

4-(4-Morpholinyl)benzoic acid, is used as an intermediate in organic synthesis. The water based additive is used in a variety of applications as a heat-sealing and anti-blocking agent.

InChI:InChI=1/C11H13NO3/c13-11(14)9-1-3-10(4-2-9)12-5-7-15-8-6-12/h1-4H,5-8H2,(H,13,14)

Upstream product

• 110-91-8 morpholine 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 934012-95-0 2-ethyl-4-fluorobenzonitrile 
• 1194-02-1 4-fluorobenzonitrile 
• 19614-15-4 4-(morpholin-4-yl)benzoic acid ethyl ester 
• 586-76-5 4-Bromobenzoic acid 
• 1204-86-0 4-(4-morpholinyl)benzaldehyde 
• 23676-05-3 4-morpholin-4-yl-benzoic acid methyl ester 
• 655-32-3 2,2,2-trifluoro-1-(4-fluorophenyl)ethanone 
• 70783-44-7 2,2,2-trifluoro-1-(4-morpholin-4-yl-phenyl)-ethanone 
• 10282-31-2 4-morpholinobenzonitrile 

Downstream Products

• 662117-33-1 6,7-dichloro-2-[4-(4-morpholinyl)phenyl]-1H-imidazo[4,5-b]pyridine 
• 1260777-79-4 4-morpholin-4-ylbenzoyl chloride hydrochloride 
• 1030830-17-1 C₂₂H₂₇N₃O₄ 
• 220051-23-0 (R)-N-[5-Bromo-8-(4-tert-butyloxycarbonylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide 
• 162848-18-2 4-(morpholin-4-yl)benzoyl chloride 
• 1022918-51-9 6-(4-Morpholinophenyl)-3-(3,4,5-trimethoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1160253-76-8 N-[(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-4-morpholin-4-ylbenzamide 

Relevant articles and documents

Buchwald-Hartwig amination reaction of aryl halides using heterogeneous catalyst based on Pd nanoparticles decorated on chitosan functionalized graphene oxide

In this work, graphene oxide was functionalized with chitosan (GO-Chit) followed by a simple approach for immobilization of palladium nanoparticles onto a chitosan grafted graphene oxide surface. The Pd-nanocomposite (GO-Chit-Pd) was characterized using Transmission Electron Microscopy (TEM), Fourier transforms infrared spectroscopy (FT-IR), and X-ray diffraction (XRD) measurements. The catalytic activity of the prepared heterogeneous graphene oxide functionalized chitosan-palladium (GO-Chit-Pd) was investigated in term of C-N coupling reaction (Buchwald-Hartwig amination reaction of aryl halides) yielding products of N-arylamines. The easy purification, convenient operation, and environmental friendliness, combined with a high yield, render this method viable for use in both laboratory research and larger industrial scales. Studying the reusability of the catalyst in this work showed that it could be reused for five times without obvious loss in catalytic activity.

Convenient Synthesis of p-Aminobenzoic Acids and their Methyl Esters

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Study of the microwave-assisted hydrolysis of nitriles and esters and the implementation of this system in rapid microwave-assisted Pd-catalyzed amination

Microwave-assisted hydrolysis of benzonitriles and methyl benzoates has been studied using a toluene/concd aq KOH two phase system in the presence and absence of phase transfer catalyst. Conditions to allow and avoid smooth hydrolysis could be identified. Based on the latter, the first microwave protocol which allows the rapid Pd-catalyzed amination of aliphatic amines with chlorobenzenes containing sensitive functional groups has been developed.