Cas 280563-35-1,{[2-([2-(bis-carboxymethyl-amino)-ethyl]-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-carboxymethyl-amino}-acetic acid

280563-35-1

Post Buying Request

Basic information

Product Name: {[2-([2-(bis-carboxymethyl-amino)-ethyl]-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-carboxymethyl-amino}-acetic acid
Synonyms: {[2-([2-(bis-carboxymethyl-amino)-ethyl]-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-carboxymethyl-amino}-acetic acid
CAS NO:280563-35-1
Molecular Formula:
Molecular Weight: 575.597
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: {[2-([2-(bis-carboxymethyl-amino)-ethyl]-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-carboxymethyl-amino}-acetic acid(CAS DataBase Reference)
NIST Chemistry Reference: {[2-([2-(bis-carboxymethyl-amino)-ethyl]-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-carboxymethyl-amino}-acetic acid(280563-35-1)
EPA Substance Registry System: {[2-([2-(bis-carboxymethyl-amino)-ethyl]-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-carboxymethyl-amino}-acetic acid(280563-35-1)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 280563-35-1(Hazardous Substances Data)

Suppliers
Usage
Upstream product
Downstream Products
Article

280563-35-1 Suppliers

Recommended suppliers

280563-35-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 280563-35-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,0,5,6 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 280563-35:
(8*2)+(7*8)+(6*0)+(5*5)+(4*6)+(3*3)+(2*3)+(1*5)=141
141 % 10 = 1
So 280563-35-1 is a valid CAS Registry Number.

280563-35-1Upstream product

280563-35-1Downstream Products

280573-59-3 Gd⁽³⁺⁾*Na⁽¹⁺⁾*(COOCH₂NCH₂COO)2(CH₂)7NCONHC₆H₄SO₂NH₂^(4-)=GdNa(COOCH₂NCH₂ COO)2(CH₂)7NCONHC₆H₄SO₂NH₂

280563-35-1Relevant academic research and scientific papers

Carbonic anhydrase inhibitors: Synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties

Scozzafava, Andrea,Menabuoni, Luca,Mincione, Francesco,Mincione, Giovanna,Supuran, Claudiu T

, p. 575 - 582 (2001)

Reaction of diethylenetriamino pentaacetic acid (dtpa) dianhydride with aromatic/heterocyclic sulfonamides possessing a free amino/imino/hydrazino/hydroxy group afforded bis-sulfonamides containing metal-complexing, polyamino-polycarboxylic acid moieties in their molecule. The corresponding mono-sulfonamide derivatives of dtpa were also obtained by an alternative method, from the free acid. Zn(II) complexes of these new sulfonamides were then prepared. Many of these derivatives showed nanomolar affinity towards isozymes I, II and IV of carbonic anhydrase (CA). Some of the best inhibitors were applied as 2% water solutions/suspensions into the eye of normotensive or glaucomatous albino rabbits, when strong and long-lasting intraocular pressure (IOP) lowering was observed.

Sulfonamide-functionalized gadolinium DTPA complexes as possible contrast agents for MRI: A relaxometric investigation

Anelli, Pier Lucio,Bertini, Ivano,Fragai, Marco,Lattuada, Luciano,Luchinat, Claudio,Parigi, Giacomo

, p. 625 - 630 (2007/10/03)

A novel Gd-DTPA derivative with a built-in sulfonamide (SA) was synthesized as a contrast agent for MRI. The complex was designed to selectively target the enzyme carbonic anhydrase. It is shown that the longitudinal relaxation rates of aqueous solutions of Gd-DTPA-SA in the presence of carbonic anhydrase increase significantly. The binding constant is determined to be 15,000 ± 5,000 M-1. This value ensures substantial formation of the carbonic anhydrase adduct at imaging concentrations of Gd- DTPA-SA. The complex interacts with erythrocytes, presumably due to a high affinity for the carbonic anhydrase present on the outer surface of the latter. This takes place even though the enzyme has a low abundance and is easily saturated by small amounts of Gd-DTPA-SA. The interaction of Gd-DTPA- SA with serum proteins is negligibly small. Therefore, the complex could potentially be tested as a selective contrast agent for compartments outside the blood pool.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 280563-35-1