67-43-6 Hazards Identification
Pictogram(s):
Signal:
Danger
GHS Hazard Statements:
H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H332: Harmful if inhaled [Warning Acute toxicity, inhalation]
H360D: May damage the unborn child [Danger Reproductive toxicity]
H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
Precautionary Statement Codes:
P203, P260, P261, P264+P265, P271, P280, P304+P340, P305+P351+P338, P317, P318, P319, P337+P317, P405, and P501
Hazard Classes and Categories:
Repr. 1B
Acute Tox. 4
STOT RE 2
Eye Irrit. 2
Eye Irrit. 2 (100%)
Acute Tox. 4 (63.03%)
Repr. 2 (77.06%)
STOT RE 2 (39.2%)
Hazards Summary:
The calcium salt causes fetal death and teratogenic effects in mice (thought to be associated with the chelation of essential divalent cations such as zinc); [REPROTOX] Causes convulsions and chronic pulmonary edema in intraperitoneal lethal-dose studies of rats (LD50 = 587 mg/kg); [RTECS] An eye irritant; [Acros Organics MSDS] See Edetic acid.
67-43-6 Usage
Uses
Used in Medical Imaging:
Diethylenetriaminepentaacetic acid is used as a chelating agent and serves as a magnetic resonance imaging (MRI) contrasting agent. It enhances the quality of MRI images by forming a complex with a gadolinium ion, which aids in visualizing internal structures more clearly.
Used in Environmental Remediation:
DTPA is employed for the treatment of radioactive materials, such as plutonium, americium, and other actinides. Its chelating properties enable it to bind with these radioactive elements, facilitating their safe disposal and containment.
Used in Agrochemical Industry:
Diethylenetriaminepentaacetic acid is an active component of manganese and zinc fertilizers used in the agrochemical industry. It helps improve the uptake of these essential nutrients by plants, promoting healthy growth and crop yields.
Used in Chemical Production:
DTPA acts as a color inhibitor and is utilized in the production of acrylon, a key component in the synthesis of various polymers and resins.
Used in Personal Care Products:
Diethylenetriaminepentaacetic acid is also used in soaps and other personal care products as a water softener. Its chelating properties help to prevent the formation of soap scum and improve the overall performance of these products.
Production Methods
Pentetic acid is a pentaacetic acid triamine formed during the
preparation of the amino carboxylic acid and its salt.
Pharmaceutical Applications
Pentetic acid is mainly used as a chelating agent in the preparation
of imaging and contrast agents for radionuclide and magnetic
resonance imaging.It is also used as a carrier excipient for
neutron-capture isotopes in, for example, radiotherapy.Pentetic
acid–isotope complexes have also been considered as model active
substances in scintigraphic imaging studies.Pentetic acid has been
used to chelate metal ions to reduce formation of reactive oxygen
species during lyophilization.
Safety Profile
Moderately toxic by
intraperitoneal route. When heated to
decomposition it emits toxic fumes of NOx.
Safety
Pentetic acid is used in intrathecal and intravenous injection
preparations. The pure form of pentetic acid is moderately toxic
by the intraperitoneal route.
LD50 (mouse, IP): 0.54 g/kg
LD50 (mouse, oral): 4.84 g/kg
storage
The activity of pentetic acid as a chelating agent may cause
unwanted effects in formulations containing metal ions. The desired
chelate may be displaced by other ions from the formulation.
Purification Methods
Crystallise DTPA from water. Dry under vacuum or at 110o. [Bielski & Thomas J Am Chem Soc 109 7761 1987, NMR: Wenzel et al. Anal Chem 54 615 1982, Beilstein 4 IV 2454.]
Incompatibilities
The activity of pentetic acid as a chelating agent may cause
unwanted effects in formulations containing metal ions. The desired
chelate may be displaced by other ions from the formulation.
Regulatory Status
Included in the FDA Inactive Ingredients Database (intrathecal and
intravenous injections). Included in intravenous and intra-articular
injections licensed in the UK.
Check Digit Verification of cas no
The CAS Registry Mumber 67-43-6 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 67-43:
(4*6)+(3*7)+(2*4)+(1*3)=56
56 % 10 = 6
So 67-43-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H13N3.5C2H4O2/c5-1-3-7-4-2-6;5*1-2(3)4/h7H,1-6H2;5*1H3,(H,3,4)
67-43-6Relevant academic research and scientific papers
Lightening Agents and/or Dyes that Contain Aldehyde(s)
-
, (2010/12/29)
Agents for dyeing and/or lightening keratin fibers, in particular human hair, containing, relative to the weight thereof, 0.001 to 15 wt. % of at least one aldehyde of the formula (I): wherein X represents —CH(R2)—SO2—Y—R1, —CR3R4R5, or wherein Y represents —CH(CHO)— or —CH2— or a chemical bond, and wherein each of R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 independently represents —H or —CN or —F or —Cl or —Br or —I or —CHO or —NH2 or —NO2 or —CF3 or —CCl3 or —CF2CF3 or —CCl2CCl3 or an optionally substituted (C1-C6) alkyl group or a hydroxyalkyl group or a polyhydroxyalkyl group or an optionally substituted (C1-C6) alkylene group, and wherein the agent contains no oxidation dye precursors of developer and coupler type.
Imaging of Enzyme Activity
-
, (2008/06/13)
This invention relates to biochemistry and magnetic resonance imaging.
Imaging thrombus with glycoprotein llb/llla antagonists
-
, (2008/06/13)
This invention relates to a method of using a radiolabeled small molecule antagonist of the platelet IIb/IIIa receptor for the diagnosis of arterial and venous thrombi.
Process for producing an amide compound
-
, (2008/06/13)
There is disclosed a process for producing an amide compound, which process is characterized in that a compound having an amino group are reacted with a polyaminopolycarboxylic acid anhydride in the presence of the polyaminopolycarboxylic acid.
Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
-
, (2008/06/13)
This invention relates to a method of using radiolabelled and/or radiopharmaceutical small molecule inhibitors of beta-amyloid peptide production for the diagnosis of neurological and other disorders involving APP processing and beta-amyloid production. Furthermore, radiolabelled small molecule inhibitors identified by the methods of the present invention would be useful in the diagnosis of neurological disorders, such as Alzheimer's disease, which involve elevated levels of Aβ peptides.
Polypeptide derivatives
-
, (2008/06/13)
A biologically active peptide selected from growth factors, peptide hormones, interferons and cytokines and analogues and derivatives thereof, and bearing at least one chelating group linked to an amino group of said peptide, the chelating group being capable of complexing a detectable element and such amino group having no significant binding affinity to target receptors, are complexed with a detectable element and are useful as a pharmaceutical, e.g. a radiopharmaceutical for in vivo imaging of target tissues or for therapy.
Water-soluble Hexadentate Schiff-base Ligands as Sequestrating Agents for Iron(III) and Gallium(III)
Evans, Dennis F.,Jakubovic, David A.
, p. 2927 - 2934 (2007/10/02)
Complexes of FeIII and GaIII with hexadentate Schiff-base ligands have been characterised in aqueous solution.They were prepared by the condensation of salicylaldehydes, containing a sulphonate or trimethylammonium group, with polyamines in the presence of the metal ions.These complexes have stabilities, at physiological pH, similar to those of the hydroxamic acid siderophore complexes.The kinetics of the displacement of FeIII from III(edta)>(1-) (edta = ethylenediamine-N,N,N',N'-tetra-acetate) by two of these ligands has been studied.
