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(+)-CIS-TRAMADOL (S)-(+)-MANDELATE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

280565-80-2

280565-80-2 Suppliers

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280565-80-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 280565-80-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,0,5,6 and 5 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 280565-80:
(8*2)+(7*8)+(6*0)+(5*5)+(4*6)+(3*5)+(2*8)+(1*0)=152
152 % 10 = 2
So 280565-80-2 is a valid CAS Registry Number.

280565-80-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (+)-CIS-TRAMADOL (S)-(+)-MANDELATE

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:280565-80-2 SDS

280565-80-2Relevant academic research and scientific papers

A practical procedure for the resolution of (+)- and (-)-tramadol

Itov, Zinovy,Meckler, Harold

, p. 291 - 294 (2000)

A practical procedure for the efficient resolution of cis-tramadol [cis-2-(dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexanol] has been developed. This process was based on the observation that cis-tramadol free base selectively formed mandelic acid salts at different rates, affording a readily scalable kinetic resolution of each enantiomer. The key to the process was the observation that the resolving salt needed to be broken and re-formed to ultimately improve the optical purity. The mandalate salt of each cis-enantiomer was found to be > 99% optically pure after three cycles through the salt formation process. A sample of each mandelate salt enantiomer was successfully converted to the known, optically active hydrochloride salt.

Development of highly efficient resolutions of racemic tramadol using mandelic acid

Evans, Graham R.,Fernandez, Paloma Diaz,Henshilwood, James A.,Lloyd, Steve,Nicklin, Chris

, p. 729 - 737 (2013/09/06)

Two methods for the resolution of tramadol are described. One uses the active pharmaceutical ingredient (API), tramadol hydrochloride as input material. The other utilises the crude free base obtained from the Grignard reaction on tramadol Mannich base. B