280573-71-9Relevant academic research and scientific papers
Synthesis and in vitro antifungal properties of 4-aryl-4-N-arylamine-1- butenes and related compounds
Kouznetsov,Urbina,Palma,Lopez,Devia,Enriz,Zacchino
, p. 428 - 430 (2000)
A new series of 4-aryl and 4-alkyl-4-N-arylamine-1-butenes (homoallylamines) were synthesized and some of them transformed to 4-aryl or alkylquinolines. All of them showed strong antifungal activities against human pathogenic fungi in vitro, being Epiderm
In vitro antifungal activity of new series of homoallylamines and related compounds with inhibitory properties of the synthesis of fungal cell wall polymers
Vargas M., Leonor Y.,Castelli, Maria V.,Kouznetsov, Vladimir V.,Urbina G., Juan M.,Lopez, Silvia N.,Sortino, Maximiliano,Enriz, Ricardo D.,Ribas, Juan C.,Zacchino, Susana
, p. 1531 - 1550 (2007/10/03)
The synthesis, in vitro antifungal evaluation and SAR studies of 101 compounds of the 4-aryl-, 4-alkyl-, 4-pyridyl or -quinolinyl-4-N-arylamino-1-butenes series and related compounds, are reported here. Active structures showed to inhibit (1,3)-β-D-glucan and mainly chitin synthases, enzymes that catalyze the synthesis of the major fungal cell wall polymers.
Inhibitors of the fungal cell wall. Synthesis of 4-aryl-4-N-arylamine-1- butenes and related compounds with inhibitory activities on β(1-3) glucan and chitin synthases
Urbina, Juan M.,Cortes, Juan C. G.,Palma, Alirio,Lopez, Silvia N.,Zacchino, Susana A.,Enriz, Ricardo D.,Ribas, Juan C.,Kouznetzov, Vladimir V.
, p. 691 - 698 (2007/10/03)
As part of our project devoted to the search for antifungal agents, which act via a selective mode of action, we synthesized a series of new 4- aryl- or 4-alkyl-N-arylamine-1-butenes and transformed some of them into 2- substituted 4-methyl-tetrahydroquin
