280576-25-2

Upstream product

• 79-04-9 chloroacetyl chloride 

Downstream Products

• 280576-27-4 2-chloro-5-methoxy-1-phenyl-1H-3-pyrrolecarbaldehyde 
• 417727-89-0 3-[di(methylsulfanyl)methylene]-5-methoxy-1-phenyl-1,3-dihydro-2H-pyrrol-2-one 
• 280576-26-3 C₁₇H₁₄N₂O₃ 
• 280576-31-0 2-[allyl(methyl)amino]-5-methoxy-1-phenyl-1H-3-pyrrolcarbaldehydeoxime 
• 280576-58-1 2-(allylsulfanyl)-5-methoxy-1-phenyl-1H-3-pyrrolcarbaldehydeoxime 
• 280576-29-6 2-[allyl(methyl)amino]-5-methoxy-1-phenyl-1H-3-pyrrolecarbaldehyde 
• 280576-53-6 2-(allylsulfanyl)-5-methoxy-1-phenyl-1H-3-pyrrolcarbaldehyde 
• 417727-98-1 3-[di(methylsulfanyl)methylene]-5-methoxy-1-phenyl-1,3-dihydro-2H-pyrrol-2-one oxime 
• 417727-92-5 2-(5-methoxy-2-oxo-1-phenyl-1,2-dihydro-3H-pyrrol-3-ylidene)malononitrile 

Relevant academic research and scientific papers

1-Aryl-5-methoxy-pyrrolones as synthons for 1,3-dipolar cycloadditions

A general method is described to convert the title compound into more complex nitrogen heterocyclic systems in a short and attractive pathway. Spiroisoxazolidine 6 was obtained from the reaction of nitrone 3 with ethyl vinyl ether. Chloroformylation of pyrrolone 2 gave 1-aryl-2-chloro-5-methoxy- pyrrol-3-carbaldehyde 4. Substitution of chlorine atom with unsaturated nucleophiles 8a,b and then modifying the aldehyde function into 1,3-dipoles 10 and 14 furnished tricyclic heterocycles 11, 12 and 15 via intramolecular 1,3-dipolar cycloaddition reaction. (C) 2000 Elsevier Science Ltd.