280581-34-2Relevant academic research and scientific papers
2,4-diamino pyrimidine compounds having anti-cell proliferative activity
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, (2008/06/13)
A pyrimidine derivative of formula (I): wherein: R1is an optional substituent as defined within; Rxis selected from halo, hydroxy, nitro, amino, cyano, mercapto, carboxy, sulphamoyl, formamido, ureido or carbamoyl or a group of formula (Ib): A—B—C— as defined within; Q1and Q2are independently selected from aryl, a 5- or 6-membered monocyclic moiety; and a 9- or 10-membered bicyclic heterocyclic moiety; and one or both of Q1and Q2bears on any available carbon atom one substituent of formula (Ia) as defined within; and Q1and Q2are optionally further substituted; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof; are useful as anti-cancer agents; and processes for their manufacture and pharmaceutical compositions containing them are described.
