280581-50-2

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-2-chloro-N-phenyl-4-pyrimidinamine is used as a building block for the synthesis of complex organic molecules, particularly in the development of new drugs and therapeutic agents. Its unique structure and chemical properties make it a valuable compound for creating innovative pharmaceutical products.
Used in Organic Chemistry Research:
In the field of organic chemistry, 5-Bromo-2-chloro-N-phenyl-4-pyrimidinamine is used as a versatile compound for conducting research and experiments. Its properties and reactivity make it a valuable tool for scientists and researchers to explore new chemical reactions and mechanisms.
Used in Biological and Medical Research:
5-Bromo-2-chloro-N-phenyl-4-pyrimidinamine also has potential applications in biological and medical research. Its unique structure and properties may contribute to the understanding of various biological processes and the development of new diagnostic or therapeutic approaches.
Overall, 5-Bromo-2-chloro-N-phenyl-4-pyrimidinamine is an important chemical compound with diverse potential applications in the chemical, pharmaceutical, and biomedical industries. Its unique structure and properties make it a valuable asset for scientists, researchers, and pharmaceutical companies in their pursuit of innovative solutions and advancements in these fields.

InChI:InChI=1/C10H7BrClN3/c11-8-6-13-10(12)15-9(8)14-7-4-2-1-3-5-7/h1-6H,(H,13,14,15)

Upstream product

• 36082-50-5 2,4-dichloro-5-bromopyrimidine 
• 62-53-3 aniline 

Downstream Products

• 358789-03-4 4-anilino-5-bromo-2-(3-carboxyanilino)pyrimidine 
• 358789-38-5 4-Anilino-5-bromo-2-[4-(aminomethyl)anilino]pyrimidine 
• 358788-86-0 4-Anilino-5-bromo-2-{4-{N-[2-(diethylamino)ethyl]carbamoyl}anilino}pyrimidine 
• 358789-22-7 anilino-5-bromo-2-(4-nitroanilino)pyrimidine 
• 790199-35-8 4-Anilino-5-bromo-2-[4-(4-methylpiperazino)anilino]pyrimidine 
• 280581-41-1 4-Anilino-5-bromo-2-[4-(2,3-epoxypropoxy)anilino]pyrimidine 
• 280581-42-2 4-anilino-5-bromo-2-(4-hydroxyanilino)pyrimidine 
• 280581-36-4 4-anilino-5-bromo-2-{4-[2-hydroxy-2-methyl-3-(isopropylamino)propoxy]anilino}pyrimidine 
• 280581-35-3 4-Anilino-5-bromo-2-(4-{N-[2-hydroxy-3-(N,N-dimethylamino)propyl]-N-methylamino}anilino)pyrimidine 
• 280581-34-2 4-Anilino-5-bromo-2-{4-[2.2-dimethyl-3-(N,N-dimethylamino)propylamino]anilino}pyrimidine 

Relevant academic research and scientific papers

Structure-activity relationship of 7-aryl-2-anilino-pyrrolopyrimidines as Mer and Axl tyrosine kinase inhibitors

The TAM (Axl, Mer, and Tyro3) family is implicated in the survival and chemoresistance of tumours and has emerged as a potential therapeutic target. A novel series of 7-aryl-2-anilino-pyrrolopyrimidines were identified as potent Axl/Mer tyrosine kinase in

NOVEL ULK1 INHIBITORS AND METHODS USING SAME

In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.

SULPHIMIDES AS PROTEIN KINASE INHIBITORS

The invention relates to sulphimides as protein kinase inhibitors of the general formula I

Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: Identification and optimisation of substituted 2,4-bis anilino pyrimidines

Through chemical modification and X-ray crystallography we identified the 2,4-bis anilino pyrimidines as potent inhibitors of CDK4. Herein, we describe the optimisation of this series.

2,4-Di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents

Pyrimidine derivatives of formula (I) wherein Q1, Q2, G and R1 are as defined within; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Processes for their manufacture, pharmaceutical compositions and their use as cyclin-dependent serine/threonine kinase (CDK) and focal adhesion kinase (FAK) inhibitors are also described.