280581-64-8

Usage

Uses

Used in Pharmaceutical Industry:
(2-chloro-5-fluoro-pyrimidin-4-yl)-phenyl-amine is used as a building block for the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable intermediate in the production of biologically active compounds, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
(2-chloro-5-fluoro-pyrimidin-4-yl)-phenyl-amine is used as a building block for the synthesis of various agrochemicals. Its potential as a pesticide or herbicide makes it a valuable component in the development of new agricultural products designed to protect crops and enhance yield.
Used in Chemical Industry:
(2-chloro-5-fluoro-pyrimidin-4-yl)-phenyl-amine is used as an important component in the chemical industry for the development of various products with pharmaceutical, agricultural, and biological applications. Its versatile properties and potential for use in multiple industries make it a valuable asset in the creation of innovative and effective products.

Upstream product

• 62-53-3 aniline 
• 2927-71-1 2,4-dichloro-5-fluoropyrimidine 

Downstream Products

• 916603-12-8 [4-(5-Fluoro-4-phenylamino-pyrimidin-2-ylamino)-benzyl]-carbamicacid tert-butyl ester 
• 1365748-86-2 C₁₁H₈FN₃O₂ 
• 1365748-89-5 C₁₃H₁₃FN₄O 

Relevant academic research and scientific papers

Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach

B-cell lymphoma 6 (BCL6) is a transcriptional factor that expresses in lymphocytes and regulates the differentiation and proliferation of lymphocytes. Therefore, BCL6 is a therapeutic target for autoimmune diseases and cancer treatment. This report presen

AURORA KINASE AND JANUS KINASE INHIBITORS FOR PREVENTION OF GRAFT VERSUS HOST DISEASE

Disclosed herein are compounds and methods for reducing the risk of developing, preventing, or treating graft versus host disease (GVHD) in a subject. The compounds can concurrently block Aurora kinase A and JAK2 signal transduction which synergistically suppresses alloreactive human T-cells in vitro, prevents xenogeneic graft- versus-host disease without impairing anti-tumor responses, and promotes the development and suppressive potency of CD39+ inducible Treg. In certain aspects, disclosed are compounds of Formula I-V.

Design, Synthesis, and Antitumor Evaluation of 4-Amino-(1H)-pyrazole Derivatives as JAKs Inhibitors

Abnormalities in the JAK/STAT signaling pathway lead to many diseases such as immunodeficiency, inflammation, and cancer. Herein, we designed and synthesized a series of 4-amino-(1H)-pyrazole derivatives as potent JAKs inhibitors for cancer treatment. Res

Facile and regioselective synthesis of novel 2,4-disubstituted-5- fluoropyrimidines as potential kinase inhibitors

2,4-Disubstituted-5-fluoropyrimidine is a biologically active molecular core seen in various anticancer agents such as 5-fluorouracil (5-FU). As part of a programme aimed at discovering kinase inhibitors, routes to two series of novel compounds (5-fluorop

Process for the identification of novel enzyme interacting compounds

The present invention relates to methods for the characterization of enzymes or of enzyme-compound complexes, wherein the enzyme is obtained from a protein preparation with the help of at least one broad spectrum ligand immobilized on a solid support and wherein the enzyme is characterized by mass spectrometry. These methods are useful for the screening of non-immobilized compound libraries, selectivity profiling of lead compounds and mechanism of action studies in living cells.

Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: Identification and optimisation of substituted 2,4-bis anilino pyrimidines

Through chemical modification and X-ray crystallography we identified the 2,4-bis anilino pyrimidines as potent inhibitors of CDK4. Herein, we describe the optimisation of this series.