280586-19-8Relevant academic research and scientific papers
2-SUBSTITUTED VITAMIN D DERIVATIVES
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Page 5-6, (2008/06/13)
The object of the present invention is to synthesize novel vitamin D derivatives. According to the present invention, there are provided vitamin D derivatives represented by the following general formula (1): wherein R1 and R2 may be
Synthesis of 2,2-dimethyl-1,25-dihydroxyvitamin D3: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators
Fujishima, Toshie,Kittaka, Atsushi,Yamaoka, Kazuyoshi,Takeyama, Ken-Ichi,Kato, Shigeaki,Takayama, Hiroaki
, p. 1863 - 1869 (2007/10/03)
A concise synthesis of all four possible A-ring stereoisomers of 2,2-dimethyl-1,25-dihydroxyvitamin D3 and characterization of their distinct transcriptional features, which appear to have been inherited from the corresponding 2α-methyl derivatives, is reported.
