558437-64-2

Upstream product

• 558437-61-9 methyl 3-(4-methoxyphenoxy)-2,2-dimethylpropionate 
• 280586-19-8 3-(4-methoxyphenoxy)-2,2-dimethylpropanol 
• 558437-62-0 3-(4-methoxyphenoxy)-2,2-dimethylpropanal 
• 14002-80-3 Methyl 2,2-dimethyl-3-hydroxypropionate 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 558437-63-1 1-(4-methoxyphenoxy)-2,2-dimethylhex-5-yn-3-ol 

Relevant academic research and scientific papers

Synthesis of 2,2-dimethyl-1,25-dihydroxyvitamin D3: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators

A concise synthesis of all four possible A-ring stereoisomers of 2,2-dimethyl-1,25-dihydroxyvitamin D3 and characterization of their distinct transcriptional features, which appear to have been inherited from the corresponding 2α-methyl derivatives, is reported.

2-SUBSTITUTED VITAMIN D DERIVATIVES

The object of the present invention is to synthesize novel vitamin D derivatives. According to the present invention, there are provided vitamin D derivatives represented by the following general formula (1): wherein R1 and R2 may be