280752-57-0

Upstream product

• 1026984-97-3 (E)-3-[3-Chloro-4-(2-hydroxymethyl-phenylsulfanyl)-phenyl]-acrylic acid 
• 1027579-93-6 3-chloro-4-(2-hydroxymethyl-phenylsulfanyl)-benzaldehyde 
• 4521-31-7 o-hydroxymethyl thiophenol 
• 34328-61-5 3-Chloro-4-fluorobenzaldehyde 
• 280748-78-9 2-(hydroxymethyl)phenyl 2-chloro-4-((E)-((1-morpholino)carbonyl)ethenyl)phenyl sulfide 

Relevant academic research and scientific papers

Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds

The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds

The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases and cerebral vasospasm, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead

The interaction between leukocyte function-associated antigen-1 (LFA-1), a member of the β2-integrin family of adhesion molecules, and intracellular adhesion molecule ICAM-1 (cd54) is thought to play a critical role in the inflammatory process.