280783-04-2Relevant academic research and scientific papers
Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors
Dang, Qun,Kasibhatla, Srinivas Rao,Jiang, Tao,Fan, Kevin,Liu, Yan,Taplin, Frank,Schulz, William,Cashion, Daniel K.,Reddy, K. Raja,Van Poelje, Paul D.,Fujitaki, James M.,Potter, Scott C.,Erion, Mark D.
experimental part, p. 4331 - 4339 (2009/05/30)
Like most phosphonic acids, the recently discovered potent and selective thiazole phosphonic acid inhibitors of fructose 1,6-bisphosphatase (FBPase) exhibited low oral bioavailability (OBAV) and therefore required a prodrug to achieve oral efficacy. Synth
