28115-04-0

Upstream product

• 2040-20-2 4-methoxyisobutyrophenone 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 874-90-8 4-methoxybenzonitrile 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 563-45-1 3-Methyl-1-butene 
• 10288-13-8 1,2-dibromo-3-methylbutane 
• 5720-07-0 4-methoxyphenylboronic acid 
• 28114-95-6 3-methyl-2-(4-methoxyphenyl)butan-2-ol 
• 17580-45-9 3-(4-methoxyphenyl)-2,2-dimethylbut-3-enoic acid 

Downstream Products

• 35144-47-9 C₁₂H₁₇O⁽¹⁺⁾ 
• 91881-09-3 4-(1,2-dimethyl-propyl)-anisole 

Relevant academic research and scientific papers

Electrochemical [4+2] Annulation-Rearrangement-Aromatization of Styrenes: Synthesis of Naphthalene Derivatives

We report the first electrochemical strategy to synthesize functionalized naphthalene derivatives through [4+2] annulation—rearrangement–aromatization from styrenes under mild conditions. The electrolysis does not require metals, oxidants and high valence substrates, indicating the atom and step-economy ideals. The dehydrodimer produced through [4+2] cycloaddition of 4-methoxy α-methyl styrene is isolated and proved to be the key intermediate for the following oxydehydrogenation to form carbon cation, which undergoes rearrangement–aromatization to afford the final products. This reaction represents a powerful access to construct multi-substituted naphthalene blocks in a single step.

Lewis Acid Catalyzed Transfer Hydromethallylation for the Construction of Quaternary Carbon Centers

The design and gram-scale synthesis of a cyclohexa-1,4-diene-based surrogate of isobutene gas is reported. Using the highly electron-deficient Lewis acid B(C6F5)3, application of this surrogate in the hydromethallylation of electron-rich styrene derivatives provided sterically congested quaternary carbon centers. The reaction proceeds by C(sp3)?C(sp3) bond formation at a tertiary carbenium ion that is generated by alkene protonation. The possibility of two concurrent mechanisms is proposed on the basis of mechanistic experiments using a deuterated surrogate.

Enantiopure C1-symmetric bis(imino)pyridine cobalt complexes for asymmetric alkene hydrogenation

Enantiopure C1-symmetric bis(imino)pyridine cobalt chloride, methyl, hydride, and cyclometalated complexes have been synthesized and characterized. These complexes are active as catalysts for the enantioselective hydrogenation of geminal-disubstituted olefins.

One-pot synthesis of substituted styrenes from vicinal dibromoalkanes and arylboronic acids

Dehydrobromination of vicinal dibromoalkanes in systems comprising 1,2-dimethoxy-ethane, N-butyl-N′-methylimidazolium tetrafluoroborate (or tetrabutylammonium bromide), and a base with subsequent palladium-catalyzed cross-coupling of the thus formed bromoalkenes with arylboronic acids furnished substituted styrenes. Springer Science+Business Media, Inc. 2007.

Stannous chloride dihydrate: A new catalyst for the tetrahydropyranylation of alcohols

Catalytic Stannous chloride dihydrate in polar aprotic solvents like chloroform efficiently catalyse the tetrahydropyranylation of alcohols in a short time under mild conditions.

Studies in Decarboxylation. Part 16. Steric Inhibition of Resonance in a 1,5-Sigmatropic Reaction

The rates of gas-phase decarboxylation of some 3-phenyl-substituted but-3-enoic acids are best rationalized in terms of steric inhibition of resonance in the more sterically crowded members.