281189-83-1Relevant academic research and scientific papers
Fluorocontaining 1,3-dicarbonyl compounds in the synthesis of pyrimidine derivatives
Burgart,Kuzueva,Pryadeina,Kappe,Saloutin
, p. 869 - 880 (2001)
Hexafluoroacetylacetone reacts with urea (thiourea) to yield respectively 4,6-bis(hydroxy)-4,6-bis(trifluoromethyl)hexahydropyrimidin-2-one(thione). The dehydration of the products and also reaction of nonsymmetrical fluoroalkyl-containing 1,3-diketones w
Biginelli condensations of fluorinated 3-oxo esters and 1,3-diketones
Saloutin,Burgart,Kuzueva,Kappe,Chupakhin
, p. 17 - 23 (2000)
Condensation of fluorinated 3-oxo esters or 1,3-diketones with benzaldehyde and (thio)urea results in the diastereoselective formation of 4-fluoroalkyl-4-hydroxy-2-oxo(thioxo)-6-phenyl-hexahydropyrimidine-5- carboxylates from which by dehydration under acidic conditions the corresponding 6-fluoroalkyl-2-oxo(thioxo)-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates were obtained. Under the same conditions, hexafluoroacetylacetone furnishes 4,6-dihydroxy-4,6-di(trifluoromethyl)-hexahydropyrimidin-2-one. Some further reactions of these pyrimidine derivatives leading to fused heterocycles are described.
