281192-54-9

Upstream product

• 98-86-2 acetophenone 
• 281192-46-9 1-[(1R)-1-(methoxymethyl)propyl]-1-(2,2,2-trifluoroethyl)hydrazine 
• 281192-45-8 (2R)-1-methoxy-N-nitroso-N-(2,2,2-trifluoroethyl)butan-2-amine 
• 281192-43-6 (1R)-N-[1-(methoxymethyl)propyl]trifluoroacetamide 
• 281192-44-7 (2R)-1-methoxy-N-(2,2,2-trifluoroethyl)butan-2-amine 
• 57883-06-4 (R)-1-(methoxymethyl)propylamine 

Relevant academic research and scientific papers

Diastereoselective LiAlH4 reduction of chiral ketone hydrazones derived from (R)-(-)-2-aminobutan-1-ol

Various chiral N,N-dialkylhydrazines were prepared in four to five steps from (R)-(-)-2-aminobutan-1-ol 6. They reacted with various prochiral ketones, thus giving the corresponding hydrazones. Reduction of the latter by means of LiAlH4 afforded N,N,N'-trisubstituted hydrazines whose d.e.s were in the range 43-100%. Interestingly, LiAlH4 reduction of the four N-trifluoroethylhydrazones 34 and 38-40 yielded the hydrazines 46 and 48-50, respectively, and with d.e.s=100% by 1H and 13C NMR. Copyright (C) 2000 Elsevier Science Ltd.