281219-45-2

Basic information

• Product Name: 4(R,S)-((S)-1-{3(R,S)-hydroxy-1-[2-(3-pyridin-2-ylphenyl)ethanoyl]azepan-4-ylcarbamoyl}-3-methylbutyl)carbamic acid tert-butyl ester
• Synonyms: 4(R,S)-((S)-1-{3(R,S)-hydroxy-1-[2-(3-pyridin-2-ylphenyl)ethanoyl]azepan-4-ylcarbamoyl}-3-methylbutyl)carbamic acid tert-butyl ester
• CAS NO: 281219-45-2
• Molecular Weight: 538.687
• Mol File: 281219-45-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4(R,S)-((S)-1-{3(R,S)-hydroxy-1-[2-(3-pyridin-2-ylphenyl)ethanoyl]azepan-4-ylcarbamoyl}-3-methylbutyl)carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4(R,S)-((S)-1-{3(R,S)-hydroxy-1-[2-(3-pyridin-2-ylphenyl)ethanoyl]azepan-4-ylcarbamoyl}-3-methylbutyl)carbamic acid tert-butyl ester(281219-45-2)
• EPA Substance Registry System: 4(R,S)-((S)-1-{3(R,S)-hydroxy-1-[2-(3-pyridin-2-ylphenyl)ethanoyl]azepan-4-ylcarbamoyl}-3-methylbutyl)carbamic acid tert-butyl ester(281219-45-2)

Safety Data

• Hazardous Substances Data: 281219-45-2(Hazardous Substances Data)

Upstream product

• 281219-34-9 4-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-hydroxy-azepan-1-carboxylic acid benzyl ester 
• 281219-32-7 allylpent-4-enylcarbamic acid benzyl ester 
• 150989-61-0 4(R,S)-amino-3(R,S)-hydroxyazepane-1-carboxylic acid benzyl ester 
• 150989-59-6 8-oxo-3-azabicyclo[5.1.0]octane-3-carboxylic acid benzyl ester 
• 150989-62-1 2,3,4,7-tetrahydro-azepine-1-carboxylic acid benzyl ester 
• 51061-68-8 3-(pyridin-2-yl)-phenyl acetic acid 
• 281219-35-0 4(R,S)-[(S)-1-(3(R,S)-hydroxyazepan-4-ylcarbamoyl)-3-methylbutyl]carbamic acid tert-butyl ester 

Downstream Products

• 281219-64-5 5-(2-Morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid ((S)-1-{3-hydroxy-1-[2-(3-pyridin-2-yl-phenyl)-acetyl]-azepan-4-ylcarbamoyl}-3-methyl-butyl)-amide 
• 281217-40-1 5-(2-Morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid ((S)-3-methyl-1-{(S)-3-oxo-1-[2-(3-pyridin-2-yl-phenyl)-acetyl]-azepan-4-ylcarbamoyl}-butyl)-amide 
• 281214-55-9 5-(2-Morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid ((S)-3-methyl-1-{(R)-3-oxo-1-[2-(3-pyridin-2-yl-phenyl)-acetyl]-azepan-4-ylcarbamoyl}-butyl)-amide 

Relevant articles and documents

Azepanone-based inhibitors of human and rat cathepsin K

The synthesis, in vitro activities, and pharmacokinetics of a series of azepanone-based inhibitors of the cysteine protease cathepsin K (EC 3.4.22.38) are described. These compounds show improved configurational stability of the C-4 diastereomeric center