28123-74-2Relevant academic research and scientific papers
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus
Moreira Osório, Thaís,Delle Monache, Franco,Domeneghini Chiaradia, Louise,Mascarello, Alessandra,Regina Stumpf, Taisa,Roberto Zanetti, Carlos,Bardini Silveira, Douglas,Regina Monte Barardi, Célia,De Fatima Albino Smania, Elza,Viancelli, Aline,Ariel Totaro Garcia, Lucas,Augusto Yunes, Rosendo,José Nunes, Ricardo,Smania Jr., Artur
supporting information; experimental part, p. 225 - 230 (2012/02/16)
The increase in antibiotic resistance due to multiple factors has encouraged the search for new compounds which are active against multidrug-resistant pathogens. In this context, chalcones, dihydrochalcones, hydrazones and oxadiazoles were tested against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus (MRSA) isolates, which were obtained from clinical laboratories and were characterized as MRSA using traditional and molecular methods. Among 65 tested compounds, two chalcones, one dihydrochalcone and two hydrazones were active against MRSA. Based on the minimal inhibitory concentration and cytotoxicity, hydrazones provided a better selectivity index than chalcones. Active hydrazones are promising antibiotic-like substances and they should be the subject of further microbiological studies.
Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides
Rando, Daniela G.,Avery, Mitchell A.,Tekwani, Babu L.,Khan, Shabana I.,Ferreira, Elizabeth I.
, p. 6724 - 6731 (2008/12/22)
A series of 53 nitro derivatives rationally designed were obtained by parallel synthesis and screened against Leishmania donovani. Six compounds exhibited IC50 values lower than standard drugs. Brief SAR analysis revealed that substitution is important to the activity. Nitrothiophene analogues were more potent than the nitrofuran ones. This was attributed to the ability of sulfur atoms in accommodating electrons from nitro group, which facilitate its reduction and therefore the formation of free radicals lethal to parasites.
Synthesis and biological activity of nifuroxazide and analogs
Tavares,Penna,Amaral
, p. 244 - 249 (2007/10/03)
Nifuroxazide and thirteen analogs were synthesized from substituted benzoic acids and minimal inhibitory concentrations were determined using the serial dilution tests, in three sequential steps. Nifuroxazide and chloramphenicol were used as reference standards. The tests were performed in TSB against the standard bacterial strain of Staphylococcus aureus ATCC 25923.
The Application of Levulinic Acid and 5-Nitro-2-furylmethylene Diacetate in the Total Synthesis of Some Novel Biologically Active (5-Nitro-2-furyl)azomethines
Vlaovic, Djordje,Cetkovic, Gordana,Juranic, Ivan,Balaz, Jelica,Lajsic, Stevan,Djokovic, Dejan
, p. 931 - 939 (2007/10/02)
The syntheses and in vitro antibacterial and antifungal evaluation of certain (5-nitro-2-furyl)azomethines with different heterocyclic nuclei are described.
Synthesis of Some Transition Metal Chelates of Furfurylidene and 5-Nitrofurfurylidene Benzoyl Hydrazones as Potential Fungicides
Rao, Surya D.,Ganorkar, M. C.
, p. 217 - 219 (2007/10/02)
Twelve complexes of the general formulae ML2 and M'L2*2H2O, where M = Ni(II), Cu(II) and Zn(II) and M' = Mn(II), Fe(II) and Co(II) and L = Furfurylidene benzoyl hydrazone (FBHZ) or 5-Nitrofurfurylidene benzoylhydrazone (5-NFBHZ), have been synthesised and characterised.The Schiff bases coordinate through O, N atoms behaving as monobasic bidentate ligands, depending on the pH of the medium.These complexes have exhibited significant fungitoxicity against Rhixoctonia solani, the causative organism of sheath blight in rice and groundnut plants.Some of the chelates exhibited more toxicity when compared to Dithane, M-45, a commercial fungicide, screened in similar conditions.The fungitoxicity of the metal chelates was found to be in the following order Cu > Ni > Fe > Zn > Mn > Co.
