28125-94-2Relevant academic research and scientific papers
Solid-phase synthesis of decalin scaffolds by Robinson annulation with immobilised Nazarov reagents
Roettger, Svenja,Waldmann, Herbert
, p. 2093 - 2099 (2006)
A method for the synthesis of natural product-inspired decalin systems on solid support is reported. It employs the Robinson annulation as key step and immobilised Nazarov reagents as key intermediates. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
Preparation of tetrahydroimidazo[2,1-a]isoquinolines and their use as inhibitors of gastric acid secretion
Palmer, Andreas Marc,Grobbel, Burkhard,Brehm, Christof,Zimmermann, Peter Jan,Buhr, Wilm,Feth, Martin Philipp,Holst, Hans Christof,Simon, Wolfgang Alexander
, p. 7647 - 7660 (2008/03/28)
A series of novel tetrahydroimidazo[2,1-a]isoquinolines was prepared based on a hetero Diels-Alder reaction between an enamine and 1,2,4-triazine as key step. A structure-activity relationship was established focussing on the influence of the substitution
7, 8, 9, 10-TETRAHYDRO-IMIDAZO[2,1-A] ISOCHINOLINES
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Page/Page column 32, (2010/02/14)
The invention provides compounds of formula (1), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.
3-amin3-arylpropan-1-ol compounds, their preparation and use
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, (2008/06/13)
3-amino-3-arylpropan-1-ol compounds of formula I: R1and R2independently denoting C1-6alkyl, or together denoting a (CH2)2-6ring optionally substituted by phenyl, R3denoting C3-6alkyl, C3-6cycloalkyl, aryl optionally containing heteroatoms and optionally substituted by R6to R8, or a substituted C1-3alkylphenyl of formula XII: ?R4and R5independently denoting C1-6alkyl, C3-6cycloalkyl, phenyl, benzyl, or phenethyl, or together forming a (CH2)3-6or CH2CH2OCH2CH2ring, R6to R8independently denoting H, F, Cl, Br, CHF2, CF3, OH, OCF3, OR14, NR15R16, SR14, phenyl, SO2CH3, SO2CF3, C1-6alkyl, CN, COOR14, or CONR15R16, or together forming a OCH2O, OCH2CH2O, CH═CHO, CH═C(CH3)O or (CH2)4ring, R14denoting C1-6alkyl, phenyl, benzyl, or phenethyl, R15and R16independently denoting H, C1-6alkyl, phenyl, benzyl or phenethyl, and A denoting optionally substituted aryl optionally containing heteroatoms, or a diastereomer or enantiomer or pharmaceutically acceptable salt thereof, and their preparation and use in pharmaceutical compositions.
Substituted 2-Phenyl- and 2-Cyclohexyl-trans-decalins, New Classes of Nematic Liquid Crystals
Petrzilka, Martin,Schleich, Kuno
, p. 1242 - 1257 (2007/10/02)
Versatile procedures for the preparation of the title compounds are described.Representatives of ketones (12 and 27), hydrocarbons (19 and 28), acids (13), esters (15 and 20), ethers (22) and nitriles (18) posses wide-range nematic phases, provided their terminal chains R2 and R3 contain at least three methylene units.
