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8-Chloroadenine is a chemical compound that belongs to the class of purine nucleobases, being a derivative of adenine with a chlorine atom attached at the 8th position. This modification endows 8-chloroadenine with distinct chemical properties, making it a valuable asset in various biological and chemical applications. It is widely recognized as a research tool in the study of nucleic acids and nucleotides, and its potential pharmaceutical applications, particularly in antiviral and anticancer medications, are under investigation. The unique characteristics of 8-chloroadenine contribute significantly to scientific research and hold promise for therapeutic advancements.

28128-28-1

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28128-28-1 Usage

Uses

Used in Scientific Research:
8-Chloroadenine is used as a research tool for studying the structure and function of nucleic acids and nucleotides, providing insights into their interactions and mechanisms within biological systems.
Used in Pharmaceutical Development:
8-Chloroadenine is used as a potential candidate in the development of antiviral and anticancer medications, leveraging its unique chemical properties to target and combat viral and cancerous cells.
Used in Chemical Synthesis:
8-Chloroadenine is utilized in the synthesis of various chemical compounds, taking advantage of its reactivity and the influence of the chlorine atom on its chemical behavior.
Used in Biochemical Analysis:
8-Chloroadenine is employed in biochemical assays and tests to evaluate the effects of modifications on adenine's interactions with enzymes, proteins, and other biomolecules, contributing to a deeper understanding of molecular recognition and binding processes.

Check Digit Verification of cas no

The CAS Registry Mumber 28128-28-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,1,2 and 8 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 28128-28:
(7*2)+(6*8)+(5*1)+(4*2)+(3*8)+(2*2)+(1*8)=111
111 % 10 = 1
So 28128-28-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H4ClN5/c6-5-10-2-3(7)8-1-9-4(2)11-5/h1-2H,(H2,7,8,9,10,11)

28128-28-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-chloro-7H-purin-6-amine

1.2 Other means of identification

Product number -
Other names Adenine,8-chloro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:28128-28-1 SDS

28128-28-1Relevant academic research and scientific papers

8-Chloroadenosine 3', 5'-cyclic monophosphate preparations

-

, (2008/06/13)

The compound 8-Chloroadenosine 3',5'-cyclic phosphate is used to treat malignant tumors in warm blooded animals. Two novel single step syntheses of 8-chloroadenosine 3',5'-cyclic phosphate and other related adenine and adenosine compounds from corresponding adenosine 3', 5'-cyclic phosphate and other respective related adenosine compounds are disclosed.

The behaviour of 6- and 8-substituted purines toward potassium amide in liquid ammonia. A new example of tele-amination

Kos, N. J.,Plas, H. C. van der,Veldhuizen, A. van

, p. 267 - 270 (2007/10/02)

Reaction of 6-chloro- and 6-(methylthio)purine with potassium amide in liquid ammonia leads to the formation of adenine.When these aminations are carried out with 15N-labelled potassium amide, the 15N label is found to be present in the amino group, proving that these reactions do not involve opening of the pyrimidine ring.Low temperature 1H- and 13C-NMR spectroscopy of solutions of 6-chloro- and 6-(methylthio)purine in liquid ammonia, containing potassium amide give no evidence for the presence of an intermediary ?-adduct. 8-Chloro- and 8-(methylthio)purine undergo a Tschitschibabin amination at position 6 leading to 8-chloro- an d 8-(methylthio)adenine.In addition 8-chloropurine gives adenine.Evidence is presented that the formation of this product proceeds via a tele-amination. 6-tert-Butyl-8-(methylthio)purine and 8-aminopurine are found to be unreactive towards potassium amide.

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