281668-98-2Relevant academic research and scientific papers
Synthesis of Air-stable, Odorless Thiophenol Surrogates via Ni-Catalyzed C?S Cross-Coupling
Magné, Valentin,Ball, Liam T.
, p. 8903 - 8910 (2019)
Thiophenols are versatile synthetic intermediates whose practical appeal is marred by their air sensitivity, toxicity and extreme malodor. Herein we report an efficient catalytic method for the preparation of S-aryl isothiouronium salts, and demonstrate that these air-stable, odorless solids serve as user-friendly sources of thiophenols in synthesis. Diverse isothiouronium salts featuring synthetically useful functionality are readily accessible by nickel-catalyzed C?S cross-coupling of (hetero)aryl iodides and thiourea. Convenient, chromatography-free isolation of these salts is achieved by precipitation, allowing the methodology to be applied directly to large scales. Thiophenols are liberated from the corresponding isothiouronium salts upon treatment with a weak base, enabling an in situ release/S-functionalization strategy that entirely negates the need to isolate, purify or manipulate these noxious reagents.
Dual H-bond activation of NHC-Au(i)-Cl complexes with amide functionalized side-arms assisted by H-bond donor substrates or acid additives
Sepp?nen, Otto,Aikonen, Santeri,Muuronen, Mikko,Alamillo-Ferrer, Carla,Burés, Jordi,Helaja, Juho
supporting information, p. 14697 - 14700 (2020/12/02)
Novel approach with amide-tethered H-bond donor NHC ligands enabled Au(i)-catalysis via H-bonding. The plain NHC-Au(i)-Cl complex catalysed conversions of terminal N-propynamides to oxazolines, and enyne cycloisomerization with an acid additive, in DCM at
Synthesis of 2,2,2-Trifluoroethyl Oxazoles, Oxazolines and Furans via Alkyne Oxytrifluoromethylation
Dong, Jia-Jia,Zhang, Song-Lin
supporting information, p. 795 - 800 (2020/01/24)
This study reports an oxytrifluoromethylation method for construction of oxazoles and furans motif and the concurrent incorporation of a 2,2,2-trifluoroethyl group at the aromatic C5-position. High-valent copper(III) trifluoromethyl compounds are crucial
PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
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Page/Page column 92; 93; 94, (2016/05/02)
Provided herein are compounds of Formula (I) and compositions useful in increasing PPARS activity. The compounds and compositions provided herein are useful for the treatment of PPARS related diseases (e.g., muscular diseases, vascular disease, demyelinat
Reductive cleavage of N-O bonds using samarium(II) iodide in a traceless release strategy for solid-phase synthesis
Myers, Rebecca M.,Langston, Steven P.,Conway, Simon P.,Abell, Chris
, p. 1349 - 1352 (2007/10/03)
(Metrix Presented) (i) p-anisoyl chloride, diisopropylethylamine, dichloromethane, 25 °C, 16 h. (ii) DBU, 4-bromobenzyl bromide, toluene, 25 °C, 48 h. (iii) SmI2/THF, 25 °C, 3 h. A strategy for making amides and ureas using a polymer-supported
