28193-66-0

Upstream product

• 4397-14-2 4-(hydroxymethyl)-2,6-dimethylphenol 
• 50-00-0 formaldehyd 
• 576-26-1 2.6-dimethylphenol 
• 50651-75-7 silver dibenzylphosphate 
• 250292-79-6 4-(4',5'-dimethoxy-α'-methyl-2'-nitrobenzyloxycarbonyloxy)-3,5-dimethylbenzyl chloride 
• 1623-08-1 phosphoric acid dibenzyl ester 
• 32692-27-6 4-chloromethyl-2,6-dimethyl-anisole 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 41763-16-0 tris-(4-hydroxy-3,5-dimethyl-benzyl)-amine 
• 5048-02-2 4-(methoxymethyl)-2,6-dimethylphenol 
• 94935-01-0 4-(4-nitrophenylaminomethyl)-2,6-xylenol 
• 294850-75-2 2,6-dimethyl-4-phenylsulfanylmethyl-phenol 
• 134778-34-0 4-(butoxymethyl)-2,6-dimethylphenol 
• 294850-78-5 2,6-dimethyl-6-methylsulfanylmethyl-4-phenylsulfanylmethyl-cyclohexa-2,4-dienone 
• 645403-83-4 ethyl-(4-butoxymethyl-2,6-dimethyl)-phenoxyacetate 
• 645403-84-5 (4-butoxymethyl-2,6-dimethylphenoxy)-acetic acid 
• 645403-85-6 (4-butoxymethyl-2,6-dimethylphenoxy)-acetyl chloride 

Relevant academic research and scientific papers

Biomolecular labeling

A method for using an organic compound to label polynucleotides is described. The method utilizes an organic compound including an oligonucleotide, and electrophilic active site, an active complex, and a phosphate binding site. The oligonucleotide has a sequence that is complimentary to a specific region of a polynucleotide. This facilitates labeling of DNA or RNA at a specific site in its sequence. The active site consists of a stable precursor, and only becomes reactive upon activation. Leaving and protecting functional groups may be attached to the active site in order to facilitate the formation of a stable precursor and subsequent activation. The active complex may be a drug, polypeptide or a reporter molecule such as an isotope or fluorescing compound. The phosphate binding sites may be any functional group capable of forming ionic bonds with phosphate oxygens. Nucleotide labeling using this compound does not interfere with a polynucleotide sequence. The described method for utilizing this compound may be performed in situ. Latent reactivity is utilized to make the reaction chemically specific, alkylating only phosphodiester groups on the polynucleotide. A lactonization reaction traps the trialkylphosphate in a stable form.

Water-Mediated Association Provides an Ion Pair Receptor

In this paper, we report on the formation and properties of a water-stabilized dimer comprising calix[4]arene-guanosine conjugate cG 2. The 1,3-alternate calixarene cG 2 was poorly soluble in dry CDCl3 and gave an ill-resolved NMR spectrum, con

Synthesis of thiophenyl substituted cyclohexa-2,4-dien-1-one and its photocleavage coupling reaction with amines

Thiophenyl substituted cyclohexa-2,4-dien-1-ones were synthesized and photolyzed in the presence of various amines to afford the amides containing diene moeties via the ketene intermediate under visible light irradiation at 38°C. (C) 2000 Elsevier Science

Anti-aids piperazines

The present invention includes diaromatic substituted heterocyclic compounds (III) STR1 which are useful in treating individuals infected with the HIV virus. The invention includes certain previously generically disclosed anti-AIDS piperazinyl compounds (V) and a method of treating HIV infected individuals with the indoles of formula (V) and the anti-AIDS amines (X).

Silica Gel as an Effective Catalyst for the Alkylation of Phenols and Some Heterocyclic Compounds

In the presence of silica gel, the reaction of phenol with t-BuBr was examined under a variety of conditions and it was found that silica gel is an effective catalyst for the alkylation.As a result of this work 2-tert-butyl-, 2,6-di-tert-butyl-, and 2,4,6-tri-tert-butylphenols, all of which are hard to obtain directly by the Friedel-Crafts process, could be prepared easily by this one-step reaction.Several other alkyl halides were also used in this reaction.The alkylations of some heterocyclic aromatic compounds which cannot be alkylated by the conventional Friedel-Crafts method were also succesfully performed by this reaction.

Kinetic Studies of the Methanolysis Reaction of Chloromethylated Phenols

The solvolysis of 25 differently substituted chloromethylated phenols was studied kinetically in methanol at 25 deg C.A sharp decrease of the initial reaction rate with increasing concentrations of added acids can be explained by a very fast solvolysis of the phenolate anions in comparison with the undissociated compounds.The latter show strictly first order kinetics up to high conversions and the rate constants can be partly correlated with the Jaffe relation.Highly negative values for the reaction constants ρ=-5.4 and ρ=-6.2 for ortho- and para-chloromethylated compounds show, that the undissociated phenols react according to the SN1-mechanism.However, deviations are found for compounds with strongly electron attracting substituents, which may be partly caused by an intramolecular catalytic effect of the phenolic hydroxy group in the case of the ortho-isomers. - Keywords: Methanolysis, Chloromethylated Phenols, Anchimeric Assistance