5048-02-2

Basic information

• Product Name: 2,6-Dimethyl-4-(methoxymethyl)phenol
• Synonyms: 2,6-Dimethyl-4-(methoxymethyl)phenol;4-Methoxymethyl-2,6-dimethylphenol
• CAS NO: 5048-02-2
• Molecular Formula: C₁₀H₁₄O₂
• Molecular Weight: 166.22
• Mol File: 5048-02-2.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,6-Dimethyl-4-(methoxymethyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dimethyl-4-(methoxymethyl)phenol(5048-02-2)
• EPA Substance Registry System: 2,6-Dimethyl-4-(methoxymethyl)phenol(5048-02-2)

Safety Data

• Hazardous Substances Data: 5048-02-2(Hazardous Substances Data)

Usage

General Description

2,6-Dimethyl-4-(methoxymethyl)phenol, also known as DMP-450, is a synthetic chemical compound commonly used as an antioxidant and inhibitor in the polymer and plastic industry. It is also used as a stabilizer in automotive, aerospace, and construction materials. DMP-450 is a light yellow liquid with a slight phenolic odor, and it is highly resistant to heat and UV radiation. This chemical is known for its ability to inhibit the oxidation and degradation of various polymer materials, effectively prolonging their lifespan and maintaining their structural integrity. Additionally, it is also used in the production of adhesives, sealants, and coatings due to its strong antioxidant properties. However, it is important to handle DMP-450 with care, as it can be harmful if inhaled or ingested and may cause skin and eye irritation.

Upstream product

• 67-56-1 methanol 
• 527-60-6 Mesitol 
• 7732-18-5 water 
• 4397-14-2 4-(hydroxymethyl)-2,6-dimethylphenol 
• 2233-18-3 4-hydroxy-3,5-dimethylbenzaldehyde 
• 576-26-1 2.6-dimethylphenol 
• 75-16-1 methylmagnesium bromide 
• 124-41-4 sodium methylate 
• 28193-66-0 4-hydroxy-3,5-dimethylbenzyl chloride 

Downstream Products

• 1013625-20-1 4-(methoxymethyl)-2,6-dimethylphenol 
• 2233-18-3 4-hydroxy-3,5-dimethylbenzaldehyde 

Relevant articles and documents

Chemoselective oxidative generation of ortho-quinone methides and tandem transformations

ortho-Quinone methides are useful transient synthetic intermediates in organic synthesis. These species are most often generated in situ by the acid- or base-mediated transformation of phenols that have been pre-functionalized at a benzylic position, or by biomimetic oxidation of the corresponding ortho-alkylphenols with metal oxidants or transition-metal complexes. Here we describe a method for the transition-metal-free oxidative generation of o-QMs from ortho-alkylarenols, using hypoiodite catalysis under nearly neutral conditions, which can then be applied in one-pot tandem reactions. This method for the chemoselective oxidative generation of ortho-quinone methides may prove superior to previous methods with respect to environmental issues and scope, and can be applied to various tandem reactions such as inter- or intramolecular [4 + 2] cycloaddition, oxa-6π-electrocyclization, conjugate addition and spiroepoxidation. [Figure not available: see fulltext.].

Selective benzylic C-C coupling catalyzed by a bioinspired dicopper complex

A highly preorganized bioinspired dicopper complex with imidazole ligation catalyzes the selective benzylic para-C-H activation of 2,4,6-trimethylphenol under aerobic conditions, yielding either the stilbenequinone or 4-methoxymethyl-2,6-dimethylphenol depending on the solvent used. The Royal Society of Chemistry.

Copper-mediated selective oxidation of a C-H bond

(Chemical Equation Presented) An environmentally friendly procedure has been developed for the oxidation of 2,4,6-trimethylpheriol (TMP) at the para Csp3-H bond. Upon reaction with H2O2 in the presence of catalytic amounts of CuII and neocuproine in methanol at 65°C, 4-(methoxymethyl)-2,6-dimethylphenol (MDP) or 4-hydroxy-3,5- dimethylbenzaldehyde (HDB) is formed (see reaction).