28223-94-1Relevant academic research and scientific papers
Transition-Metal-Free C(sp3)–S Coupling in Water: Synthesis of Benzyl Dithiocarbamates Using Thiuram Disulfides as an Organosulfur Source
Peng, Han-Ying,Dong, Zhi-Bing
, p. 949 - 956 (2018/11/27)
A simple, highly efficient and environmentally benign method for the synthesis of benzyl dithiocarbamates was reported. Without addition of metal catalyst, a series of 34 benzyl dithiocarbamates were obtained in good to excellent yields by treating benzyl halides with tetraalkylthiuram disulfides in water. The protocol allows easy access to C(sp3)–S bond formation, features the advantages of easy performance, environmental friendliness, good to excellent yields, and good functional tolerance, showing potential value for the preparation of some biologically active compounds.
An Efficient Synthesis of Benzyl Dithiocarbamates by Base-Promoted Cross-Coupling Reactions of Benzyl Chlorides with Tetraalkylthiuram Disulfides at Room Temperature
Wu, Zhiyong,Lai, Miao,Zhang, Siyuan,Zhong, Xianyun,Song, Hao,Zhao, Mingqin
supporting information, p. 7033 - 7036 (2019/01/04)
A straightforward, mild and efficient protocol for the synthesis of benzyl dithiocarbamates from benzyl chlorides and tetraalkylthiuram disulfides is presented. This protocol is compatible with a wide variety of electron-donating and -withdrawing substituents and enables construction of various dithiocarbamate derivatives from readily available starting materials.
