28225-88-9

Usage

Uses

Used in Agriculture Industry:
2,4-dichloro-5-methylthiophenol is used as a fungicide and bactericide for controlling various plant diseases and promoting crop health.
Used in Chemical Manufacturing:
2,4-dichloro-5-methylthiophenol is used as a raw material in the production of dyes and other organic compounds, contributing to the synthesis of various chemical products.
It is important to handle and dispose of 2,4-dichloro-5-methylthiophenol with care due to its potential health hazards and environmental impact. Protective measures should be taken when working with this chemical compound to ensure safety.

InChI:InChI=1/C7H6Cl2S/c1-4-2-7(10)6(9)3-5(4)8/h2-3,10H,1H3

Upstream product

• 28286-86-4 2,4-dichloro-5-methyl-benzenesulfonyl chloride 
• 95-73-8 2,4-dichlorotoluene 
• 88519-69-1 C₁₄H₁₀Cl₄S₂ 

Downstream Products

• 71735-21-2 2-[(2,4-dichloro-5-methylphenyl)sulfanyl]acetic acid 
• 64454-26-8 Ethyl(2.4-dichlor-5-methylphenylthiovinyl)ether 
• 64454-20-2 2.4-Dichlor-5-methylphenylthioacetaldehyd-diethylacetal 
• 1137560-51-0 .4-[(2,4-dichloro-5-methylphenyl)sulfanyl]-3,5-dinitrobenzonitrile 
• 1137560-49-6 2-[(2,4-dichloro-5-methylphenyl)sulfanyl]-1,3-dinitro-5-methylbenzene 
• 1137560-47-4 2-[(2,4-dichloro-5-methylphenyl)sulfanyl]-1,5-dinitro-3-(trifluoromethyl)benzene 
• 1137560-53-2 2-[(2,4-dichloro-5-methylphenyl)sulfanyl]-1,3,5-tris(trifluoromethyl)benzene 
• 1137560-38-3 2-[(2,4-dichloro-5-methylphenyl)sulfanyl]-1,3-dinitrobenzene 

Relevant academic research and scientific papers

Redox-active dinitrodiphenylthioethers against Leishmania: Synthesis, structure-activity relationships and mechanism of action studies

BTB 06237 (2-[(2,4-dichloro-5-methylphenyl)sulfanyl]-1,3-dinitro-5-(trifluoromethyl) benzene), a compound previously identified through QSAR pharmacophore development and a virtual screen of the Maybridge database, possesses potent and selective activity against Leishmania parasites. In the present study, several analogs of BTB 06237 were synthesized and analyzed for activity against Leishmania axenic amastigotes, their ability to reduce the level of parasitemia in peritoneal macrophages, and their ability to generate reactive oxygen species (ROS) in L. donovani promastigotes. It was found that an aromatic ring must be present in the position occupied by the 2,4-dichloro-5-methylphenyl group in the lead compound, but changing the functional groups generally has little effect on the antileishmanial potency. Alterations to the 1,3-dinitro-5-(trifluoromethyl)benzene ring have more influence on antiparasitic activity with two aromatic nitro groups and a third electron-withdrawing group being required. This structural requirement corresponds with redox potential, the ability to generate ROS in the parasites, and dissipation of the mitochondrial membrane potential. Finally, we used this collection of data to design a new antileishmanial compound with strong activity in vitro and improved properties as an antileishmanial candidate.