28233-34-3

Usage

Natural source

Roots of the Indian trumpet flower (Ochrosia elliptica)

Family

Acridone alkaloids

Anticancer activity

Inhibits the growth of cancer cells

Antimalarial activity

Potential treatment for malaria

Molecular structure

a. Three hydroxyl groups (-OH)
b. Two 3-methyl-2-butenyl side chains

Unique and complex molecule

Due to the presence of multiple functional groups and side chains

Therapeutic applications

Promising potential in the development of new drugs for cancer and malaria treatment

Upstream product

• 108937-60-6 3,5-Dibenzyloxy-1-hydroxy-2,4-bis(3,3-dimethylallyl)-N-methylacridone 
• 108937-59-3 3,5-Dibenzyloxy-1-hydroxy-2,4-bis(3,3-dimethylallyl)acridone 
• 108937-58-2 1,3-dihydroxy-2,4-bis(3,3-dimethylallyl)-5-benzyloxyacridone 
• 108937-63-9 1,3-dihydroxy-5-benzyloxyacridone 
• 85990-01-8 1-hydroxy-3,5-dimethoxy-9(10H)-acridinone 
• 85990-00-7 1,3,5-trihydroxy-9(10H)-acridinone 
• 115-18-4 2-methyl-3-buten-2-ol 
• 63110-81-6 1,3-dihydroxy-5-methoxy-9(10H)-acridinone 

Relevant academic research and scientific papers

Synthesis of Acridone Alkaloids: Glycocitrine-I, N-Methylatalphylline, Atalphyllidine, 11-Hydroxyacronycine and 11-Hydroxynoracronycine

Selective benzylation of 1,3,5-trihydroxyacridone (3) results in 5-benzylated acridone (6), which on prenylation affords a mixture of monoprenylated acridone (7) and diprenylated acridone (9).Treatment of 7 with methyl iodide followed by hydrogenolysis furnishes glycocitrine-I (1). 9 on benzylation, followed by N-methylation and debenzylation yields N-methylatalphylline (2).Condensation of 6 with 3-hydroxyisovaleraldehyde dimethylacetal results in 15, which on hydrogenolysis furnishes atalphyllidine (12). 15 on methylation affords N-methylacridone (16) and N,O-dimethylacridone (17).Compounds 16 and 17 on hydrogenolysis afford 11-hydroxynoracronycine (13) and 11-hydroxyacronycine (14), respectively.