28241-62-5

Usage

Uses

Used in Pharmaceutical Industry:
4-METHYL-5-PHENYL-THIAZOL-2-YLAMINE is used as a pharmaceutical compound for its broad spectrum of biological activities. Its antimicrobial, antifungal, and anti-tumor properties make it a promising candidate for the development of new drugs to treat various diseases.
Used in Drug Development:
In drug development, 4-METHYL-5-PHENYL-THIAZOL-2-YLAMINE serves as a key component in the creation of novel therapeutic agents. Its potential to target multiple biological pathways and disease mechanisms positions it as a valuable asset in the advancement of medicinal chemistry.
Used in Medicinal Chemistry:
4-METHYL-5-PHENYL-THIAZOL-2-YLAMINE is utilized in medicinal chemistry for its capacity to interact with biological systems, offering a foundation for the design and synthesis of new pharmaceuticals aimed at treating a variety of health conditions.

InChI:InChI=1/C10H10N2S/c1-7-9(13-10(11)12-7)8-5-3-2-4-6-8/h2-6H,1H3,(H2,11,12)

Upstream product

• 23022-83-5 1-bromo-1-phenyl-2-propanone 
• 17356-08-0 thiourea 
• 4773-35-7 1-chloro-1-phenylpropan-2-one 
• 103-79-7 1-phenyl-acetone 
• 90915-10-9 4-methyl-3-oxy-5-phenyl-thiazol-2-ylamine 
• 33992-53-9 (1-chloroprop-2-yn-1-yl)benzene 
• 28241-61-4 ammonia thiocyanic acid 
• 22596-45-8 2-methyl-2-nitro-3-phenyloxirane 
• 420-04-2 CYANAMID 
• 20772-12-7 1-bromo-3-phenyl-2-propanone 
• 95337-89-6 2,5-dimethyl-1-(5-methyl-4-phenylthiazol-2-yl)pyrrole 

Downstream Products

• 299219-56-0 C₁₀H₈BrNS 
• 1619233-78-1 2-((4-methyl-5-phenylthiazol-2-yl)amino)-2-oxoethyl 4-(3-(dimethylamino)propyl)piperazine-1-carbodithioate 
• 1619233-77-0 2-((4-methyl-5-phenylthiazol-2-yl)amino)-2-oxoethyl 4-(2-(dimethylamino)ethyl)piperazine-1-carbodithioate 
• 1619233-76-9 2-((4-methyl-5-phenylthiazol-2-yl)amino)-2-oxoethyl 4-ethylpiperazine-1-carbodithioate 
• 50772-55-9 PCM-0102788 
• 94547-22-5 2-acetoxy-N-(4-methyl-5-phenyl-thiazol-2-yl)-2-phenyl-acetamide 

Relevant academic research and scientific papers

Synthetic method of 4,5-disubstituted-2-aminothiazole compound

The invention discloses a synthetic method of a 4,5-disubstituted-2-aminothiazole compound. The synthetic method sequentially comprises the following steps: 1) making a nitro-epoxy compound react withammonium thiocyanate in the presence of a solvent and an alkali catalyst at the temperature of 40-/+5 DEG C for 10 to 14 hours; 2) adding water into reaction liquid prepared in the step 1), extracting the mixture with ethyl acetate, washing a prepared organic layer, drying the organic layer, and performing concentration with a rotary evaporator; 3) performing silica gel column chromatography on the concentrate prepared in the step 2) to obtain the 4,5-disubstituted-2-aminothiazole compound. The method for synthesizing the 4,5-disubstituted-2-aminothiazole compound disclosed by the invention has the characteristics of adoption of readily-available raw materials, mild reaction conditions, high yield, convenience in post treatment and the like.

Efficient and facile strategy to substituted 2-aminothiazoles via ring opening of α-nitroepoxides

A novel and efficient reaction has been developed to synthesize a set of substituted 2-aminothiazoles from α-nitroepoxides and ammonium thiocyanate. This reaction could proceed smoothly at mild condition, to afford products for a wide range of substrates with good to excellent yields. A possible mechanism has also been proposed.

One-pot three-component protocol for the synthesis of substituted 2-aminothiazoles

Substituted 2-aminothiazoles have been synthesized from α-nitro-epoxides, cyanamide, and sodium sulfide through a facile, three-component, and ecofriendly protocol with good to excellent yields. This reaction was achieved at room temperature without any additives. A possible mechanism has also been proposed.

Synthesis of 5-Phenylthiazolamines by Using Thiourea as an α-Bromination Shuttle

A straightforward synthesis of 5-phenylthiazolamines by coupling thiourea with phenylacetones, phenylacetophenones, and β-tetralone has been developed. Thiourea acts as a substrate and an α-bromination shuttle by transferring a Br atom from CBrCl3/s

Facile, efficient synthesis of polysubstituted thiazoles via α-nitroepoxides and thioureas

An efficient synthesis of 2,4,5-trisubstituted thiazoles via the reaction of α-nitroepoxides and thioureas under mild conditions has been developed. This reaction proceeded well at room temperature, to afford products in excellent yields for a wide range

Preparation method of 4,5-disubstituted-2-substituted aminothiazole compound

The invention discloses a preparation method of a 4,5-disubstituted-2-substituted aminothiazole compound. The preparation method comprises steps as follows: 1), nitro epoxy compounds and thiourea compounds react at the room temperature for 4-8 h in the pr

Azole derivatives as histamine H3 receptor antagonists, Part I: Thiazol-2-yl ethers

Most human histamine H3 receptor (hH3R) antagonists follow a general structural blueprint, containing a basic moiety linked by a spacer to a substituted core element. In this investigation the acceptance of thiazol-2-yl ether moieties in the core region is proved with some ether derivatives showing hH3R binding affinities in the nanomolar concentration range. A diversity of structural motifs is used as substituents to enhance the in vitro hH3R binding affinity.

Facile Synthesis of Aminothiazoles

The reaction of thioureas with ketones in the presence of N-bromosuccinimide furnishes 2-aminothiazoles.The method is quick, convenient and versatile.

Protection of Primary Amines as N-Substituted 2,5-Dimethylpyrroles

Protection of primary amine group is achieved by incorporating it into an N-substituted 2,5-dimethylpyrrole system.The method affords protection against strong bases and nucleophiles, heating with concentrated alkali, standard mineral acid work-up conditions, and various other reagents.Phenyl-, pyridil-, thiazolyl-, and alkyl-amines have been studied.All give trisubstituted pyrroles in high yield (>80percent) by reaction with hexane-2,5-dione.The pyrroles from the first three types are stable to storage; even the N-alkyl compounds can be used without difficulty.Regeneration of the amine group, by treatment with hydrxylamine hydrochloride, is efficient (80percent yield) with the phenyl, pyridyl, and alkyl compounds but less satisfactory (60 - 65percent generally but down to 25percent in two cases) with the thiazolyl derivatives.