299219-56-0Relevant academic research and scientific papers
Azole derivatives as histamine H3 receptor antagonists, Part I: Thiazol-2-yl ethers
Walter,Von Coburg,Isensee,Sander,Ligneau,Camelin,Schwartz,Stark
supporting information; experimental part, p. 5879 - 5882 (2010/11/18)
Most human histamine H3 receptor (hH3R) antagonists follow a general structural blueprint, containing a basic moiety linked by a spacer to a substituted core element. In this investigation the acceptance of thiazol-2-yl ether moieties in the core region is proved with some ether derivatives showing hH3R binding affinities in the nanomolar concentration range. A diversity of structural motifs is used as substituents to enhance the in vitro hH3R binding affinity.
