28246-89-1Relevant academic research and scientific papers
Aminoalkyl phenyl sulfones - A novel series of 5-HT7 receptor ligands
Raubo, Piotr,Beer, Margaret S.,Hunt, Peter A.,Huscroft, Ian T.,London, Clare,Stanton, Josephine A.,Kulagowski, Janusz J.
, p. 1255 - 1258 (2007/10/03)
A novel series of 5-HT7 receptor ligands has been identified and evaluated, providing compounds showing a broad spectrum of functional activities and good selectivity over selected receptors and ion channels.
Sulfone derivatives as 5-HT7 receptor ligands
-
Page/Page column 6, (2010/02/09)
The present invention relates to sulfone derivatives of formula (I): Ar—SO2—CR2R3-L-N(R1)2??I wherein Ar, L, R1, R2 and R3 are as defined herein, and pharmaceutically
Stereospecific Dehydrative Alkylation of Bis-Sulfones: Synthesis of a Lesser Tea Tortrix Pheromone
Yu, Jurong,Cho, Hyun-Sung,Falck, J. R.
, p. 5892 - 5894 (2007/10/02)
The intra- and intermolecular condensation of alcohols with bis-sulfone methylenes, i.e., dehydrative alkylation, using DEAD and Ph3P proceeds stereospecifically at room temperature under essentially neutral conditions affording good to excellent yields o
TRANSITION STATES IN INTRAMOLECULAR SN2 REACTIONS OF CARBANIONS. THE CLOSURE OF THREE-, FOUR- AND FIVE-MEMBERED RINGS
Benedetti, Fabio,Fabrissin, Silvio,Rusconi, Alessandro,Stirling, Charles J. M.
, p. 233 - 240 (2007/10/02)
The intramolecular displacement of aryl ethyl sulphonium by carbanions stabilised by two sulphonyl groups has been studied.Rates of cyclisation of three-, four- and five-membered rings follow the same trend observed in the analogous displacement of halides.The effects of substituents on the leaving group show that, in the series considered, variations in the extent of bond cleavage to the leaving group are small.
Phase Transfer Catalysed Alkylations of Bis(benzenesulfonyl)methane
Koteswar Rao, Y.,Nagarajan, M.
, p. 1031 - 1033 (2007/10/02)
Alkylations of bis(benzenesulfonyl)methane under phase transfer catalysed conditions are reported.Variations in the phase transfer catalyst, alkylating reagent and the cosolvent have been studied with a view to understanding the course of the reaction.Opt
Elimination and Addition Reactions. Part 40. The Insignificant Effect of Strain in Higher Order Eliminations in 1,1-bis(phenylsulphonyl) Carbanions with ω-Leaving Groups
Benedetti, Fabio,Stirling, Charles J.M.
, p. 605 - 612 (2007/10/02)
Rates of cyclisation of 1,1-bis(phenylsulphonyl) carbanions bearing distal leaving groups have been determined.The response of the system to solvent effects and to leaving group is similar to that in intramolecular nucleophilic substitution.The system is
Activation Parameters for Intramolecular Nucleophilic Substitution by Carbanions - the Insignificant Effect of Ring Strain on Cylisation Rates
Benedetti, Fabio,Stirling, Charles J. M.
, p. 1374 - 1376 (2007/10/02)
Activation parameters for the cyclisation of bis-sulphonyl-stabilised carbanions to bis-sulphonylcycloalkanes have been determined; cyclopropanes form nearly a million-fold faster than cyclobutanes and ring strain is a negligible factor in determining rea
