28248-37-5Relevant academic research and scientific papers
Asymmetric hydrogenation via capture of active intermediates generated from aza-pinacol rearrangement
Yu, Chang-Bin,Huang, Wen-Xue,Shi, Lei,Chen, Mu-Wang,Wu, Bo,Zhou, Yong-Gui
, p. 15837 - 15840 (2014)
An efficient palladium-catalyzed asymmetric hydrogenation via capture of an active intermediate generated in situ from acid-catalyzed aza-Pinacol rearrangement has been successfully developed, providing efficient access to chiral exocyclic amines with up to 98% ee. Three-, four-, and five-membered cyclic N-sulfonyl amino alcohols are viable substrates. This study opens a new window to the application of asymmetric hydrogenation.
SYNTHESIS OF SOME I-AMINO ALICYCLIC CARBOXYLIC ACIDS AND THEIR DERIVATIVES
CREMLYN RJW,ELLAM RM,MITRA TK
, p. 218 - 220 (2007/10/08)
A number of isomeric 1-amino alicyclic carboxylic acids have been prepared via the Bucherer and Strecker routes. These amino acids have been converted into the corresponding copper complexes; p- toluenesulphonyl derivatives of the methyl esters of the amino acids have also been prepared. It is observed that the p- toluenesulphonyl derivatives of the methyl esters of Bucherer amino acids are generally obtained in higher yields as compared with the derivatives of Strecker amino acids, under identical experimental conditions.
