282532-76-7

Upstream product

• 4145-51-1 3-O-Benzyl-1-O-octadecanoyl-sn-glycerin 
• 112-67-4 n-hexadecanoyl chloride 
• 57-11-4 stearic acid 
• 57-10-3 1-hexadecylcarboxylic acid 
• 56552-80-8 (R)-3-benzyloxy-1,2-propanediol 
• 112-76-5 Stearoyl chloride 

Downstream Products

• 1346691-01-7 1-O-(2,3,4,6-tetra-O-methoxyacetyl-α-D-mannopyranosyl)-3-O-benzyl-2-O-(((S)-2-O-hexadecanoyloxy-3-O-octadecanoyloxypropyl)(benzyl)phosphoryl)-DL-glycerol 
• 1346691-02-8 C₆₀H₁₀₁O₁₅P 
• 228406-23-3 O-benzyl O-(2R)-2-hexadecanoyloxy-3-octadecanoyloxypropyl-N,N-diisopropyl phosphoramidite 

Relevant academic research and scientific papers

Total synthesis and mass spectrometric analysis of a: Mycobacterium tuberculosis phosphatidylglycerol featuring a two-step synthesis of (R)-tuberculostearic acid

We report the total synthesis of (R)-tuberculostearic acid-containing Mycobacterium tuberculosis phosphatidylglycerol (PG). The approach features a two-step synthesis of (R)-tuberculostearic acid, involving an (S)-citronellyl bromide linchpin, and the pho

Phosphatidyl myo-inositol mannosides mimics built on an acyclic or heterocyclic core: Synthesis and anti-inflammatory properties

Phosphatidyl myo-inositol mannosides (PIMs) are constituents of the mycobacterial cell wall and possess immunomodulatory activities. Certain PIM derivatives have immunoprotective activity and are of interest as anti-inflammatory agents. In order to identi

SYNTHETIC ANALOGUES OF PHOSPHATIDYL-MYO-INOSITOL MANNOSIDES WITH AN INHIBITORY ACTIVITY OF THE INFLAMMATORY RESPONSE

The present invention relates to novel synthetic analogues of phosphatidyl-myo-inositol mannosides (hereinafter referred to as PIMs) of general formula (I): or a pharmaceutically acceptable salt thereof, to the method for preparing same and to the use thereof in the prevention or treatment of a disease associated with the overexpression of cytokines or of chemokines, in particular of TNF and/or of IL-12. The invention also relates to a pharmaceutical composition comprising at least one synthetic derivative of PIM.

Phosphorylation of unnatural phosphatidylinositols with phosphatidylinositol 3-kinase

Phosphatidylinositol analogs (PI(C2)-PI(C18)) having a series of saturated fatty acid (C2-C18) at sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol 3-kinase (PI 3- kinase). The reactivity of Pica with PI 3-kinase turned out to be comparable to that of natural PI, although PI(C18) was not phosphorylated under the same condition. The chirality of sn-2 center was not responsible for the phosphorylation reaction. (C) 2000 Elsevier Science Ltd.