282549-48-8

Basic information

• Product Name: 3-(4-fluorophenyl)indolin-2-one
• Synonyms: 3-(4-fluorophenyl)indolin-2-one
• CAS NO: 282549-48-8
• Molecular Weight: 227.238
• Mol File: 282549-48-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-(4-fluorophenyl)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-fluorophenyl)indolin-2-one(282549-48-8)
• EPA Substance Registry System: 3-(4-fluorophenyl)indolin-2-one(282549-48-8)

Safety Data

• Hazardous Substances Data: 282549-48-8(Hazardous Substances Data)

Upstream product

• 91-56-5 indole-2,3-dione 
• 352-13-6 4-flourophenylmagnesium bromide 
• 59-48-3 2-oxoindole 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 79419-73-1 (RS)-3-(4-fluorophenyl)-3-hydroxy-indolin-2-one 

Downstream Products

• 1255502-52-3 (S)-3-(4-fluorophenyl)-3-(naphthalen-1-ylmethyl)indolin-2-one 
• 1289108-37-7 tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-3-(4-fluorophenyl)-2-oxoindoline-1-carboxylate 
• 1289108-81-1 tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-3-(4-fluorophenyl)-2-oxoindoline-1-carboxylate 
• 862907-06-0 tert-butyl 3-(4-fluorophenyl)-2-oxoindoline-1-carboxylate 
• 79419-73-1 (RS)-3-(4-fluorophenyl)-3-hydroxy-indolin-2-one 

Relevant articles and documents

Asymmetric organocatalytic α-amination of 2-oxindoles with bis(2,2,2-trichloroethyl)azo-dicarboxylate

An enantioselective electrophilic amination of 3-substituted-2-oxindoles is reported, using bis(2,2,2-trichloroethyl)azo-dicarboxylate and commercially available Cinchona alkaloid organocatalysts. The best results were obtained in the reaction of 3-aryl s

Organocatalytic stereoselective conjugate addition of 3-substituted oxindoles with in situ generated ortho-quinone methides

A novel method for the stereoselective conjugate addition of 3-substituted oxindoles to in situ generated o-QMs was described. This process was catalyzed efficiently by a cinchonidine-derived squaramide catalyst in oil-water phase, furnishing the corresponding 3,3-disubsituted oxindole derivatives in moderate to high yields (up to 98%) with high stereoselectivities (up to 95% ee, 15.4:1 dr). The utility of this reaction was also investigated by the gram-scale synthesis and derivatization of one of the products.

In situ generation of electrophilic trifluoromethylthio reagents for enantioselective trifluoromethylthiolation of oxindoles

An organocatalytic asymmetric trifluoromethylthiolation reaction via in situ generation of active electrophilic trifluoromethylthio species involving trichloroisocyanuric acid and AgSCF3 as a practical and easily handled electrophilic SCF3 source for CSP 3-SCF3 bond formation was developed. Reactions with this one-pot version strategy occurred in good yields and excellent stereoselectivities to access enantiopure oxindoles bearing a SCF 3-substituted quaternary chiral center. The straightforward process described here makes use of simple starting materials and proceeds under mild conditions, which will be useful in medicinal chemistry and diversity-oriented syntheses.