28255-39-2

Basic information

• Product Name: DIETHYL(4-HYDROXYPHENYL)PHOSPHONATE
• Synonyms: CHEMPACIFIC 60130;DIETHYL(4-HYDROXYPHENYL)PHOSPHONATE;(4-HYDROXY-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER;Diethyl(4-hydroxyphenyl)phosphonate, min. 98 %;4-diethoxyphosphorylphenol
• CAS NO: 28255-39-2
• Molecular Formula: C₁₀H₁₅O₄P
• Molecular Weight: 230.2
• Mol File: 28255-39-2.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DIETHYL(4-HYDROXYPHENYL)PHOSPHONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL(4-HYDROXYPHENYL)PHOSPHONATE(28255-39-2)
• EPA Substance Registry System: DIETHYL(4-HYDROXYPHENYL)PHOSPHONATE(28255-39-2)

Safety Data

• Hazardous Substances Data: 28255-39-2(Hazardous Substances Data)

Upstream product

• 42822-57-1 diethyl (4-aminophenyl)phosphonate 
• 540-38-5 p-Iodophenol 
• 122-52-1 triethyl phosphite 
• 14221-01-3 tetrakis(triphenylphosphine) palladium⁽⁰⁾ 
• 23197-23-1 4-hydroxyphenylhydrazine 
• 762-04-9 phosphonic acid diethyl ester 
• 99-96-7 4-hydroxy-benzoic acid 
• 1927-95-3 4-bromophenyl acetate 
• 106-41-2 4-bromo-phenol 
• 89620-99-5 silver diethyl phosphonate 
• 762-04-9 Diethyl phosphonate 
• 25944-72-3 diethyl p-acetoxyphenylphosphonate 
• 68574-35-6 4-bromophenyl methanesulfonate 
• 211055-48-0 Methanesulfonic acid 4-(diethoxy-phosphoryl)-phenyl ester 

Downstream Products

• 1137726-84-1 hexakis[4-(diethoxyphosphoryl)phenoxy]cyclotriphosphazene 
• 33795-18-5 4-hydroxybenzenephosphonic acid 
• 1093121-02-8 C₃₁H₃₅N₂O₁₀PS₂ 
• 77173-37-6 4-hydroxyphenyl phosphonic acid monoethyl ester 
• 1443991-86-3 3,4-bis(4-methylphenyl)-1-ethoxy-6-hydroxy-benz[c-1,2]oxaphosphinine 1-oxide 

Relevant articles and documents

Diethyl boronobenzylphosphonates as substrates in Suzuki–Miyaura reaction

N-substituted boronobenzylphosphonates were evaluated as substrates in Suzuki–Miyaura coupling catalyzed by tetrakis(triphenylphosphine)palladium(0) and complex of palladium acetate and (2-biphenyl)dicyclohexylphosphine. It was proven that they may be con

Decarbonylative Phosphorylation of Carboxylic Acids via Redox-Neutral Palladium Catalysis

We describe the direct synthesis of organophosphorus compounds from ubiquitous aryl and vinyl carboxylic acids via decarbonylative palladium catalysis. The catalytic system shows excellent scope and tolerates a wide range of functional groups (>50 examples). The utility of this powerful methodology is highlighted in the late-stage derivatization directly exploiting the presence of the prevalent carboxylic acid functional group. DFT studies provided insight into the origin of high bond activation selectivity and P(O)-H isomerization pathway.

A copper-catalyzed variant of the Michaelis-Arbuzov reaction

As part of our studies on copper-catalyzed arylation of nucleophiles, we report on Michaelis-Arbuzov reactions with a novel catalytic system, featuring a copper(I) salt as precatalyst without any additional ligand. This procedure is an interesting alternative to the use of expensive and toxic transition metals (nickel, palladium) traditionally used as catalysts in Michaelis-Arbuzov reactions. Our approach allows the synthesis from triethylphosphite, diethyl aryl phosphonite, and diaryl ethylphosphinite of various aryl phosphonates, aryl phosphinates, and aryl phosphine oxides, respectively. These families of compounds are essential owing to their respective importance in bioorganic and medical chemistry, their applicability as flame retardants, and their usability in coordination chemistry and catalysis. Copper load of this! The first copper-catalyzed Michaelis-Arbuzov reactions are described. The methodology is ligand-free and allows the direct synthesis of various aryl phosphonates, aryl phosphinates, and aryl phosphine oxides from aryl iodides.