28272-93-7

Usage

Uses

Used in Nuclear Industry:
N,N''-BIS-(2-CHLORO-PHENYL)-MALONAMIDE is used as a selective extractant for the separation and purification of metal ions, particularly uranium and thorium. Its application is crucial in the processes of nuclear fuel reprocessing, where it aids in the efficient extraction of these metal ions from aqueous solutions.
Used in Environmental Remediation:
In the field of environmental remediation, N,N''-BIS-(2-CHLORO-PHENYL)-MALONAMIDE serves as an effective agent for the extraction of rare earth elements and actinides from contaminated aqueous solutions. This helps in mitigating the environmental impact of heavy metal pollution and contributes to the cleanup of contaminated sites.
Used in Metal Recycling:
N,N''-BIS-(2-CHLORO-PHENYL)-MALONAMIDE is utilized in metal recycling processes to selectively extract valuable metal ions, thus facilitating the recovery and reuse of these metals. Its high efficiency in solvent extraction processes makes it a preferred choice in the recycling industry.

Upstream product

• 504-64-3 carbon suboxide 
• 95-51-2 o-chloroaniline 
• 105-53-3 diethyl malonate 
• 1663-67-8 malonoyl dichloride 

Downstream Products

• 105678-77-1 2,2-Dichloro-N¹,N³-bis-(2-chloro-phenyl)-propanediimidoyl dichloride 

Relevant academic research and scientific papers

Synthesis, spectral features and biological activity of some novel hetarylazo dyes derived from 8-chloro-4-hydroxyl-2-quinolone

In this study, 8-chloro-4-hydroxyl-2-quinolone was synthesized from cyclocondensation of corresponding dianilide and subsequently used as a potent coupling component with some diazotized heterocyclic amines. These compounds were characterized by UV-vis, F

Ligand-based modelling followed by synthetic exploration unveil novel glycogen phosphorylase inhibitory leads

Glycogen phosphorylase (GP) is a valid anti-diabetic target. Accordingly, we applied a drug discovery workflow to unveil novel inhibitory GP leads via combining pharmacophore modeling, QSAR analysis and in silico screening, followed by synthetic exploration of active hits. Virtual screening identified six low micromolar inhibitory leads from the National Cancer Institute (NCI) list of compounds. The most potent hits exhibited anti-GP IC50 values of 3.2 and 4.1 μM. Synthetic exploration of hit 59 (IC50 = 4.1 μM) yielded 25 lead inhibitors with the best illustrating IC50 of 3.0 μM. Interestingly, we prepared several novel mixed oxalyl amide anti-GP leads employing new chemical reaction involving succinic acid-based adducts.