282723-22-2

Usage

Uses

Used in Pharmaceutical Research and Development:
2-Isopropoxy-3-chloropyridine is used as a research chemical for its potential anti-cancer and anti-inflammatory properties. It is employed in the study of phosphatidylinositol 3-kinase (PI3K) inhibition, which is a key pathway in cancer and inflammatory diseases.
Used in Biochemical Studies:
IPA-3 is utilized as a biochemical research tool to understand the mechanisms of action and the effects of PI3K inhibition on cellular processes, which can contribute to the development of new therapeutic agents.
Used in Drug Development:
2-Isopropoxy-3-chloropyridine is used as a lead compound in the development of new drugs targeting the PI3K pathway, which is implicated in various diseases, including cancer and inflammatory conditions.
Used in Agriculture:
Although not explicitly mentioned in the provided materials, due to its unique chemical properties, 2-Isopropoxy-3-chloropyridine may have potential applications in agriculture, possibly as a component in the development of new pesticides or herbicides, given its ability to inhibit specific biological pathways.
Used in the Pharmaceutical Industry:
In the pharmaceutical industry, 2-Isopropoxy-3-chloropyridine is used as a precursor in the synthesis of various pharmaceutical compounds, potentially leading to the creation of new medications with anti-cancer and anti-inflammatory effects.

Upstream product

• 2402-77-9 2,3-dichloro-pyridine 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 1443430-81-6 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-N-[(dimethylamino)sulfonyl]difluorobenzamide 
• 1443431-23-9 N-(azetidin-1-ylsulfonyl)-4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzamide 
• 1443431-25-1 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoic acid 
• 1443432-66-3 ethyl 4-{[(5-chloro-6-isopropoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoate 
• 1211531-67-7 5-bromo-3-chloro-2-isopropoxypyridine 
• 1446444-36-5 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-N-[(methylamino)sulfonyl]-2,5-difluorobenzamide 
• 1446444-65-0 4-((5-chloro-6-isopropoxypyridin-3-yl)oxy)-2,5-difluoro-N-(N-(4-methoxybenzyl)-N-methylsulfamoyl)benzamide 
• 1446444-64-9 4-((5-chloro-6-isopropoxypyridin-3-yl)oxy)-2,5-difluorobenzamide 
• 1446444-68-3 tert-butyl 4-((5-chloro-6-isopropoxypyridin-3-yl)oxy)-2,5-difluorobenzoate 
• 1446444-66-1 4-((5-chloro-6-isopropoxypyridin-3-yl)oxy)-2,5-difluorobenzoic acid 
• 1355066-41-9 5-chloro-6-(1-propan-2-yloxy)-3-pyridinol 
• 903886-71-5 6-isopropoxypyridin-3-ol 

Relevant academic research and scientific papers

Cycloalkyl-substituted mesyl benzamide derivatives, and preparation method and medical application thereof

The invention relates to cycloalkyl-substitutedmesyl benzamide derivatives, and a preparation method and medical application thereof. The invention particularly discloses compounds disclosed as Formula (I) or pharmaceutically acceptable salts, stereoisomers, solvated compounds or prodrugs thereof, and a preparation method and application thereof. All the groups in the formula are defined in the specification.

SUBSTITUTED BENZOXAZOLES AND METHODS OF USE THEREOF

The invention provides compounds having the general formula (I): and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, Rsup

SULFONAMIDE DERIVATIVES

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav 1

N-AMINOSULFONYL BENZAMIDES

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulphonamide Nav 1.7 inhibitors of formula (I) or a pharmaceutically acceptable salt thereof, wherein Z, R1a, R1b, R2, R3, R4 and R5 are as defined in the description. Nay 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain

CHEMICAL COMPOUNDS

PC71695A Abstract Chemical Compounds The invention relates to sulfonamide derivatives, to their use in medicine, to 5 compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I):10 X NH O S O O R1 R2 R5 R4 R3 Het1 (I) or a pharmaceutically acceptable salt thereof, wherein X, Het1, R1, R2, R3, R4 and R5 are as defined in the description. 15 Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

CHEMICAL COMPOUNDS

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula 10 (I): (I) or a pharmaceutically acceptable salt thereof, wherein Z, R 1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

CHEMICAL COMPOUNDS

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Het1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain

Substituted 3,4-pyridynes: Clean cycloadditions

The stabilisation of 3,4-pyridyne (1) by an alkoxy group adjacent to the ring nitrogen is reported. The regioselective lithiation of 2-ethoxy- (14), 2-methoxy- (18), 2-isopropoxy- (19) and 6-isopropoxy- (26) -3-chloropyridines with tertbutyllithium at low temperatures, followed by elimination of lithium chloride affords 2- and 6-alkoxy-3,4-pyridynes. These species are trapped m situ with furan in a Diels-Alder reaction to give 5-8 in 66-89% yield, and do not give products typical of polymerisation or nucleophilic addition to the 3,4-pyridyne intermediates. As a comparison treatment of 3-chloropyridine with furan and LDA gives only 19% of adduct (4). We also report the novel use of the isopropoxy (rather than methoxy) group in these systems, which can act as a heteroatomic electron donating group which inhibits a-lithiation by tert-butyllithium because of its increased steric bulk. The Royal Society of Chemistry 2000.