28276-04-2

Upstream product

• 87743-10-0 3-((dimethylamino)methyl)-4-hydroxy-5-methoxybenzaldehyde 
• 121-33-5 vanillin 
• 87743-11-1 Acetic acid 2-acetoxymethyl-4-formyl-6-methoxy-phenyl ester 
• 107-30-2 chloromethyl methyl ether 
• 15454-33-8 chloromethanol 

Downstream Products

• 150900-50-8 3-(Benzothiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-benzaldehyde 
• 1225374-38-8 (5-formyl-2-hydroxy-3-methoxybenzyl)triphenylphosphonium chloride 
• 80547-80-4 3,4-dimethoxy-5-methylbenzaldehyde 
• 3153-96-6 1,2-dimethoxy-3-methyl-5-(2-nitro-vinyl)benzene 
• 46274-23-1 2-(3,4-dimethoxy-5-methylphenyl)ethan-1-amine 
• 1198079-04-7 C₂₄H₂₈N₂O₆S₂ 
• 625836-67-1 (E)-3-[3-(Benzothiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamide 

Relevant academic research and scientific papers

Tetrahydrocoptisine derivative and applications thereof

The present invention relates to a compound as shown in a formula (VII), a preparation method and applications thereof in medicines. In particular, the present invention relates to a derivative of the compound as shown in the formula (VII), a preparation method, and the applications of the derivative used as a therapeutic agent in prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, II-type diabetes, hyperglycemia, obesity or insulin resistance syndrome and metabolic syndrome. The compound disclosed by the present invention can also reduce total cholesterol, LDL-cholesterol and triglyceride, and increases expression of a liver LDL receptor and decreases expression of PCSK9.

An expeditious and convergent synthesis of ailanthoidol

An expeditious and concise method has been described for the synthesis of ailanthoidol through convergent route starting from vanillin. The protocol involving intramolecular Wittig as a key reaction afforded ailanthoidol in overall high yield.

NOVEL MODULATORS OF PROTEIN KINASE SIGNALING

The present invention provides new tyrphostin derivatives acting as protein kinase (PK) and receptor kinase (RK) signaling modulators. The invention further provides methods of their preparation, pharmaceutical compositions including such compounds, and m